Pro- and anti-inflammatory cytokines: the hidden keys to autoimmune gastritis therapy

Greta Cascetta; Giorgia Colombo; Gianmarco Eremita; Joe G.N. Garcia; Marco Vincenzo Lenti; Antonio Di Sabatino; Cristina Travelli

doi:10.3389/fphar.2024.1450558

Pro- and anti-inflammatory cytokines: the hidden keys to autoimmune gastritis therapy

Greta Cascetta, Giorgia Colombo, Gianmarco Eremita, Joe G.N. Garcia, Marco Vincenzo Lenti, Antonio Di Sabatino, Cristina Travelli

Research output: Contribution to journal › Review article › peer-review

1 Scopus citations

Abstract

Autoimmune gastritis (AIG) is an autoimmune disorder characterized by the destruction of gastric parietal cells and atrophy of the oxyntic mucosa which induces intrinsic factor deficiency and hypo-achlorhydria. AIG predominantly affects the antral mucosa with AIG patients experiencing increased inflammation and a predisposition toward the development of gastric adenocarcinoma and type I neuroendocrine tumors. The exact pathogenesis of this autoimmune disorder is incompletely understood although dysregulated immunological mechanisms appear to major contributors. This review of autoimmune gastritis, an unmet medical need, summarizes current knowledge on pro- and anti-inflammatory cytokines and strategies for the discovery of novel biomarkers and potential pharmacological targets.

Original language	English (US)
Article number	1450558
Journal	Frontiers in Pharmacology
Volume	15
DOIs	https://doi.org/10.3389/fphar.2024.1450558
State	Published - 2024
Externally published	Yes

Keywords

autoimmune atrophic gastritis
cytokine
immune system
inflammation
therapy

ASJC Scopus subject areas

Pharmacology
Pharmacology (medical)

Access to Document

10.3389/fphar.2024.1450558

Cite this

@article{a9eddd507ce746f18f628bc38993506a,

title = "Pro- and anti-inflammatory cytokines: the hidden keys to autoimmune gastritis therapy",

abstract = "Autoimmune gastritis (AIG) is an autoimmune disorder characterized by the destruction of gastric parietal cells and atrophy of the oxyntic mucosa which induces intrinsic factor deficiency and hypo-achlorhydria. AIG predominantly affects the antral mucosa with AIG patients experiencing increased inflammation and a predisposition toward the development of gastric adenocarcinoma and type I neuroendocrine tumors. The exact pathogenesis of this autoimmune disorder is incompletely understood although dysregulated immunological mechanisms appear to major contributors. This review of autoimmune gastritis, an unmet medical need, summarizes current knowledge on pro- and anti-inflammatory cytokines and strategies for the discovery of novel biomarkers and potential pharmacological targets.",

keywords = "autoimmune atrophic gastritis, cytokine, immune system, inflammation, therapy",

author = "Greta Cascetta and Giorgia Colombo and Gianmarco Eremita and Garcia, {Joe G.N.} and Lenti, {Marco Vincenzo} and {Di Sabatino}, Antonio and Cristina Travelli",

note = "Publisher Copyright: Copyright {\textcopyright} 2024 Cascetta, Colombo, Eremita, Garcia, Lenti, Di Sabatino and Travelli.",

year = "2024",

doi = "10.3389/fphar.2024.1450558",

language = "English (US)",

volume = "15",

journal = "Frontiers in Pharmacology",

issn = "1663-9812",

publisher = "Frontiers Media SA",

}

TY - JOUR

T1 - Pro- and anti-inflammatory cytokines

T2 - the hidden keys to autoimmune gastritis therapy

AU - Cascetta, Greta

AU - Colombo, Giorgia

AU - Eremita, Gianmarco

AU - Garcia, Joe G.N.

AU - Lenti, Marco Vincenzo

AU - Di Sabatino, Antonio

AU - Travelli, Cristina

PY - 2024

Y1 - 2024

N2 - Autoimmune gastritis (AIG) is an autoimmune disorder characterized by the destruction of gastric parietal cells and atrophy of the oxyntic mucosa which induces intrinsic factor deficiency and hypo-achlorhydria. AIG predominantly affects the antral mucosa with AIG patients experiencing increased inflammation and a predisposition toward the development of gastric adenocarcinoma and type I neuroendocrine tumors. The exact pathogenesis of this autoimmune disorder is incompletely understood although dysregulated immunological mechanisms appear to major contributors. This review of autoimmune gastritis, an unmet medical need, summarizes current knowledge on pro- and anti-inflammatory cytokines and strategies for the discovery of novel biomarkers and potential pharmacological targets.

AB - Autoimmune gastritis (AIG) is an autoimmune disorder characterized by the destruction of gastric parietal cells and atrophy of the oxyntic mucosa which induces intrinsic factor deficiency and hypo-achlorhydria. AIG predominantly affects the antral mucosa with AIG patients experiencing increased inflammation and a predisposition toward the development of gastric adenocarcinoma and type I neuroendocrine tumors. The exact pathogenesis of this autoimmune disorder is incompletely understood although dysregulated immunological mechanisms appear to major contributors. This review of autoimmune gastritis, an unmet medical need, summarizes current knowledge on pro- and anti-inflammatory cytokines and strategies for the discovery of novel biomarkers and potential pharmacological targets.

KW - autoimmune atrophic gastritis

KW - cytokine

KW - immune system

KW - inflammation

KW - therapy

UR - http://www.scopus.com/inward/record.url?scp=85202008389&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85202008389&partnerID=8YFLogxK

U2 - 10.3389/fphar.2024.1450558

DO - 10.3389/fphar.2024.1450558

M3 - Review article

AN - SCOPUS:85202008389

SN - 1663-9812

VL - 15

JO - Frontiers in Pharmacology

JF - Frontiers in Pharmacology

M1 - 1450558

ER -

Pro- and anti-inflammatory cytokines: the hidden keys to autoimmune gastritis therapy

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this