TY - JOUR
T1 - Primary biliary tract malignancies
T2 - MRI spectrum and mimics with histopathological correlation
AU - Mittal, Pardeep K.
AU - Moreno, Courtney Coursey
AU - Kalb, Bobby
AU - Mittal, Ankush
AU - Camacho, Juan C.
AU - Maddu, Kiran
AU - Kitajima, Hiroumi D.
AU - Quigley, Brian C.
AU - Kokabi, Nima
AU - Small, William C.
N1 - Publisher Copyright:
© 2014, Springer Science+Business Media New York.
PY - 2015/8/12
Y1 - 2015/8/12
N2 - Contrast-enhanced magnetic resonance imaging and magnetic resonance cholangiopancreatography (MRCP), due to their excellent soft tissue contrasts, have become first-line noninvasive tests in the characterization and detection of both hepatic and pancreaticobiliary pathologies. MRCP is also helpful in detecting the level and cause of obstruction in patients presenting with jaundice. Cholangiocarcinoma (CCA) is the most common primary malignant tumor arising from the bile duct epithelium, with extrahepatic tumors presenting more often than with intrahepatic ones. However, the diagnosis and management of CCA is made more complex by a variety of malignant and benign conditions that resemble CCA, including hepatocellular carcinoma variants such as the fibrolamellar variant of hepatocellular carcinoma, cholangiocellular carcinoma, biliary metastases, hepatic inflammatory pseudotumor, lymphoepithelioma-like carcinoma, confluent fibrosis, primary sclerosis cholangitis, and the secondary sclerosing cholangitis complex. Consequently, knowledge of the underlying risk factors and imaging characteristics of these conditions is important in differentiating between neoplastic and non-neoplastic conditions in order to reach a definite diagnosis. Endoscopic retrograde cholangiopancreatography should be reserved for those patients who require intervention or biopsy for histopathological diagnosis.
AB - Contrast-enhanced magnetic resonance imaging and magnetic resonance cholangiopancreatography (MRCP), due to their excellent soft tissue contrasts, have become first-line noninvasive tests in the characterization and detection of both hepatic and pancreaticobiliary pathologies. MRCP is also helpful in detecting the level and cause of obstruction in patients presenting with jaundice. Cholangiocarcinoma (CCA) is the most common primary malignant tumor arising from the bile duct epithelium, with extrahepatic tumors presenting more often than with intrahepatic ones. However, the diagnosis and management of CCA is made more complex by a variety of malignant and benign conditions that resemble CCA, including hepatocellular carcinoma variants such as the fibrolamellar variant of hepatocellular carcinoma, cholangiocellular carcinoma, biliary metastases, hepatic inflammatory pseudotumor, lymphoepithelioma-like carcinoma, confluent fibrosis, primary sclerosis cholangitis, and the secondary sclerosing cholangitis complex. Consequently, knowledge of the underlying risk factors and imaging characteristics of these conditions is important in differentiating between neoplastic and non-neoplastic conditions in order to reach a definite diagnosis. Endoscopic retrograde cholangiopancreatography should be reserved for those patients who require intervention or biopsy for histopathological diagnosis.
KW - Cholangiocarcinoma (CCA)
KW - Magnetic resonance imaging (MRI)
KW - Primary sclerosing cholangitis (PSC)
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U2 - 10.1007/s00261-014-0300-0
DO - 10.1007/s00261-014-0300-0
M3 - Article
C2 - 25416002
AN - SCOPUS:84938949222
SN - 0942-8925
VL - 40
SP - 1520
EP - 1557
JO - Abdominal Imaging
JF - Abdominal Imaging
IS - 6
ER -