Prevention and treatment of aortic graft infection

Firas F. Mussa, Nasim Hedayati, Wei Zhou, Hosam F. El-Sayed, Panagiotis Kougias, Rabih O. Darouiche, Peter H. Lin

Research output: Contribution to journalReview articlepeer-review

27 Scopus citations


Prosthetic vascular graft infection remains one of the most challenging surgical problems for vascular surgeons. This condition is classically associated with high morbidity and mortality rates. Accurate diagnosis of a vascular graft infection can typically be made based on a thorough history and physical examination; although, infrequently, an extensive radiological evaluation is necessary to establish the clinical finding. Complete graft excision and extra-anatomic bypass grafting remains a commonly accepted surgical treatment strategy. Recent clinical data have supported other treatment modalities, including the use of in situ antibiotic-impregnated graft replacement, in situ allograft replacement and in situ autologous graft replacement. This article will review the pathobiology of aortic graft infection, as well as methods to prevent a prosthetic graft infection. Furthermore, various surgical treatment modalities of aortic graft infection will be discussed.

Original languageEnglish (US)
Pages (from-to)305-315
Number of pages11
JournalExpert Review of Anti-Infective Therapy
Issue number2
StatePublished - Apr 2007
Externally publishedYes


  • Allograft
  • Aortoenteric fistula
  • Cryopreserved vascular graft
  • Extra-anatomic bypass
  • Vascular graft excision
  • Vascular graft infection

ASJC Scopus subject areas

  • Microbiology
  • Microbiology (medical)
  • Virology
  • Infectious Diseases


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