Preventing depression in older adults

Jordan F. Karp, Eric Lenze, Lalith Solai, Jules Rosen, Charles F. Reynolds

Research output: Contribution to journalArticlepeer-review


Late-life depression (LLD) is a devastating disease, complicating medical illnesses and their management. In addition to treating LLD, prevention of the disorder should be a priority, as identifying and modifying risk factors can pave the way for more effective intervention efforts. This article contrasts the Institute of Medicine's classification of prevention (universal, selective, indicated) with classic public health definitions (primary, secondary, tertiary) and describes how these terms are applied to LLD. The authors focus on three areas for prevention of LLD: 1) enabling access to effective treatment; 2) preventing the development of depression in high-risk individuals; and 3) treating mood disorders to complete remission to prevent recurrence. Medical, psychosocial, and genetic risk factors are described, as is work from the author's own laboratory in the area of LLD prevention.

Original languageEnglish (US)
Pages (from-to)69-80
Number of pages12
JournalClinical Neuropsychiatry
Issue number1
StatePublished - Feb 2006
Externally publishedYes


  • Late-life depression (LLD)
  • Prevention

ASJC Scopus subject areas

  • Psychiatry and Mental health

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