TY - JOUR
T1 - Prevalence of MRI-detected mediopatellar plica in subjects with knee pain and the association with MRI-detected patellofemoral cartilage damage and bone marrow lesions
T2 - Data from the Joints on Glucosamine study
AU - Hayashi, Daichi
AU - Xu, Li
AU - Guermazi, Ali
AU - Kwoh, C. Kent
AU - Hannon, Michael J.
AU - Jarraya, Mohamed
AU - Green, Stephanie M.
AU - Jakicic, John M.
AU - Moore, Carolyn E.
AU - Roemer, Frank W.
N1 - Funding Information:
No authors have conflict of interest that may inappropriately bias this study within the last 3 years. However, we would like to disclose the following: AG is the President of Boston Imaging Core Lab (BICL) LLC, and a consultant to Merck Serono, Stryker, Genzyme, AstraZeneca, and Novartis. FWR is the CMO of BICL, LLC, and a consultant to Merck Serono and National Institute of Health. CKK received funding from AstraZeneca and the Beverage Institute, and is a consultant to Novartis.
Funding Information:
The Joins On Glucosamine Study was supported by a research grant from the Coca-Cola Company Beverage Institute for Health & Wellness. However, the sponsor did not have any role in study design, data analysis and interpretation, writing of the report and the decision to submit the paper for publication.
PY - 2013
Y1 - 2013
N2 - Background: The mediopatellar plica is a synovial fold representing an embryonic remnant from the developmental process of the synovial cavity formation in the knee. We aimed to examine the frequency of MRI-detected mediopatellar plica and its cross-sectional association with MRI-detected cartilage damage and bone marrow lesions (BMLs) in the patellofemoral joint (PFJ) in a cohort of subjects with knee pain. Methods. 342 knees with chronic frequent knee pain were evaluated for MRI-detected mediopatellar plica (type A, B or C according to the modified Sakakibara classification). Cartilage damage (scored 0 to 6) and BMLs (scored 0 to 3) were semiquantitatively assessed in four subregions of the PFJ on MRI. Hoffa-synovitis and effusion-synovitis were graded 0 to 3. Patellar length ratio (PLR), lateral patellar tilt angle (LPTA), bisect offset (BO), and sulcus angle (SA) were measured on MRI. The presence of mediopatellar plica and its association with cartilage damage and BMLs in the PFJ was assessed using logistic regression after adjusting for age, gender, body mass index, PLR, LPTA, BO, SA, and Hoffa- and effusion-synovitis. Results: 163 (47.7%) knees exhibited mediopatellar plica (76 (22.2%) type A, 69 (20.2%) type B, and 18 (5.3%) type C) on MRI. Significant cross-sectional associations of MRI-detected mediopatellar plica and cartilage damage were observed for the medial patella (adjusted odds ratio (aOR) 2.12, 95% CI 1.23-3.64 for all types combined, and aOR 4.20, 95% CI 1.92-9.19 for type B lesion), but not for the anterior medial femur or the lateral PFJ. No associations were found between the presence of MRI-detected mediopatellar plica and BMLs in any patellofemoral subregion. Conclusion: On MRI, types A and B mediopatellar plicae were commonly observed in this cohort of subjects with knee pain. MRI-detected mediopatellar plica was cross-sectionally associated with higher likelihood of the presence of MRI-detected medial patellar cartilage damage after adjustment for confounders.
AB - Background: The mediopatellar plica is a synovial fold representing an embryonic remnant from the developmental process of the synovial cavity formation in the knee. We aimed to examine the frequency of MRI-detected mediopatellar plica and its cross-sectional association with MRI-detected cartilage damage and bone marrow lesions (BMLs) in the patellofemoral joint (PFJ) in a cohort of subjects with knee pain. Methods. 342 knees with chronic frequent knee pain were evaluated for MRI-detected mediopatellar plica (type A, B or C according to the modified Sakakibara classification). Cartilage damage (scored 0 to 6) and BMLs (scored 0 to 3) were semiquantitatively assessed in four subregions of the PFJ on MRI. Hoffa-synovitis and effusion-synovitis were graded 0 to 3. Patellar length ratio (PLR), lateral patellar tilt angle (LPTA), bisect offset (BO), and sulcus angle (SA) were measured on MRI. The presence of mediopatellar plica and its association with cartilage damage and BMLs in the PFJ was assessed using logistic regression after adjusting for age, gender, body mass index, PLR, LPTA, BO, SA, and Hoffa- and effusion-synovitis. Results: 163 (47.7%) knees exhibited mediopatellar plica (76 (22.2%) type A, 69 (20.2%) type B, and 18 (5.3%) type C) on MRI. Significant cross-sectional associations of MRI-detected mediopatellar plica and cartilage damage were observed for the medial patella (adjusted odds ratio (aOR) 2.12, 95% CI 1.23-3.64 for all types combined, and aOR 4.20, 95% CI 1.92-9.19 for type B lesion), but not for the anterior medial femur or the lateral PFJ. No associations were found between the presence of MRI-detected mediopatellar plica and BMLs in any patellofemoral subregion. Conclusion: On MRI, types A and B mediopatellar plicae were commonly observed in this cohort of subjects with knee pain. MRI-detected mediopatellar plica was cross-sectionally associated with higher likelihood of the presence of MRI-detected medial patellar cartilage damage after adjustment for confounders.
KW - Bone marrow lesion
KW - Cartilage
KW - Knee
KW - MRI
KW - Mediopatellar plica
UR - http://www.scopus.com/inward/record.url?scp=84885334761&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84885334761&partnerID=8YFLogxK
U2 - 10.1186/1471-2474-14-292
DO - 10.1186/1471-2474-14-292
M3 - Article
C2 - 24119160
AN - SCOPUS:84885334761
SN - 1471-2474
VL - 14
JO - BMC Musculoskeletal Disorders
JF - BMC Musculoskeletal Disorders
M1 - 292
ER -