Prevalence of depression in adults with haemophilia

M. Iannone, L. Pennick, A. Tom, H. Cui, M. Gilbert, K. Weihs, A. T. Stopeck

Research output: Contribution to journalArticlepeer-review

44 Scopus citations


Multiple factors place adults with haemophilia at risk for depression. Health outcomes can be compromised in depressed patients secondary to increased risk taking behaviour and poor compliance with treatment recommendations. To assess the prevalence and risk factors associated with depression in adult patients with haemophilia treated at a haemophilia treatment centre. Adults with haemophilia were screened for depression during their annual clinic visit using the Patient Health Questionnaire 9 (PHQ-9), a validated tool for depression screening in adults. Depression was defined as a PHQ-9 score ≥ 5. Risk factors associated with depression were collected by chart review and correlated with depression scores. A total of 41 adult patients consented to the study and 37% met criteria for depression. Fifty-three per cent of patients with depression reported moderate to severe symptoms of depression (PHQ-9 score >10). Seventy-six per cent of patients with depression reported suffering functional impairment due to their depressive symptoms. Lack of social support and unemployment were significantly associated with higher PHQ-9 scores (P = 0.04 and P = 0.01 respectively). Adult patients with haemophilia have a high prevalence of depression. The addition of depression screening to the comprehensive care of adults with haemophilia may result in improved overall health outcomes and treatment adherence.

Original languageEnglish (US)
Pages (from-to)868-874
Number of pages7
Issue number6
StatePublished - Nov 2012


  • Adults
  • Depression
  • Haemophilia
  • PHQ-9

ASJC Scopus subject areas

  • Hematology
  • Genetics(clinical)


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