Pretreatment with the polyamine analog 1,19-bis-(ethylamino)-5,10,15-triazanonadecane (BE-4-4-4-4) inhibits etoposide cytotoxicity in U-251 MG (NCI) human brain tumor cells.

I. V. Smirnov; B. G. Feuerstein; M. Pellarin; L. J. Marton; D. F. Deen; H. S. Basu

Pretreatment with the polyamine analog 1,19-bis-(ethylamino)-5,10,15-triazanonadecane (BE-4-4-4-4) inhibits etoposide cytotoxicity in U-251 MG (NCI) human brain tumor cells.

I. V. Smirnov
, B. G. Feuerstein
, M. Pellarin
, L. J. Marton
, D. F. Deen
, H. S. Basu

Medicine Administration

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

We studied whether pretreatment of U-251 MG human brain tumor cells with the polyamine analog 1,19-bis-(ethylamino)-5,10,15-triazanonadecane (BE-4-4-4-4) affected the cytotoxicity of the topoisomerase II inhibitor etoposide. We found that BE-4-4-4-4 protected cells from the cytotoxic effects of etoposide. Possible mechanisms for this protection may be related to enhanced DNA-nuclear matrix association in analog-treated cells.

Original language	English (US)
Pages (from-to)	975-980
Number of pages	6
Journal	Cellular and molecular biology (Noisy-le-Grand, France)
Volume	40
Issue number	7
State	Published - Nov 1994

ASJC Scopus subject areas

Biochemistry
Molecular Biology
Cell Biology

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Pretreatment with the polyamine analog 1,19-bis-(ethylamino)-5,10,15-triazanonadecane (BE-4-4-4-4) inhibits etoposide cytotoxicity in U-251 MG (NCI) human brain tumor cells. / Smirnov, I. V.; Feuerstein, B. G.; Pellarin, M. et al.
In: Cellular and molecular biology (Noisy-le-Grand, France), Vol. 40, No. 7, 11.1994, p. 975-980.

Research output: Contribution to journal › Article › peer-review

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abstract = "We studied whether pretreatment of U-251 MG human brain tumor cells with the polyamine analog 1,19-bis-(ethylamino)-5,10,15-triazanonadecane (BE-4-4-4-4) affected the cytotoxicity of the topoisomerase II inhibitor etoposide. We found that BE-4-4-4-4 protected cells from the cytotoxic effects of etoposide. Possible mechanisms for this protection may be related to enhanced DNA-nuclear matrix association in analog-treated cells.",

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AU - Smirnov, I. V.

AU - Feuerstein, B. G.

AU - Pellarin, M.

AU - Marton, L. J.

AU - Deen, D. F.

AU - Basu, H. S.

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Pretreatment with the polyamine analog 1,19-bis-(ethylamino)-5,10,15-triazanonadecane (BE-4-4-4-4) inhibits etoposide cytotoxicity in U-251 MG (NCI) human brain tumor cells.

Abstract

ASJC Scopus subject areas

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