Pretreatment with the polyamine analog 1,19-bis-(ethylamino)-5,10,15-triazanonadecane (BE-4-4-4-4) inhibits etoposide cytotoxicity in U-251 MG (NCI) human brain tumor cells.

I. V. Smirnov; B. G. Feuerstein; M. Pellarin; L. J. Marton; D. F. Deen; H. S. Basu

Pretreatment with the polyamine analog 1,19-bis-(ethylamino)-5,10,15-triazanonadecane (BE-4-4-4-4) inhibits etoposide cytotoxicity in U-251 MG (NCI) human brain tumor cells.

I. V. Smirnov, B. G. Feuerstein, M. Pellarin, L. J. Marton, D. F. Deen, H. S. Basu

Medicine Administration

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

We studied whether pretreatment of U-251 MG human brain tumor cells with the polyamine analog 1,19-bis-(ethylamino)-5,10,15-triazanonadecane (BE-4-4-4-4) affected the cytotoxicity of the topoisomerase II inhibitor etoposide. We found that BE-4-4-4-4 protected cells from the cytotoxic effects of etoposide. Possible mechanisms for this protection may be related to enhanced DNA-nuclear matrix association in analog-treated cells.

Original language	English (US)
Pages (from-to)	975-980
Number of pages	6
Journal	Cellular and molecular biology (Noisy-le-Grand, France)
Volume	40
Issue number	7
State	Published - Nov 1994

ASJC Scopus subject areas

Biochemistry
Molecular Biology
Cell Biology

Cite this

Pretreatment with the polyamine analog 1,19-bis-(ethylamino)-5,10,15-triazanonadecane (BE-4-4-4-4) inhibits etoposide cytotoxicity in U-251 MG (NCI) human brain tumor cells. / Smirnov, I. V.; Feuerstein, B. G.; Pellarin, M. et al.
In: Cellular and molecular biology (Noisy-le-Grand, France), Vol. 40, No. 7, 11.1994, p. 975-980.

Research output: Contribution to journal › Article › peer-review

@article{cc3d044f8ea44e9dbe42c62679137767,

title = "Pretreatment with the polyamine analog 1,19-bis-(ethylamino)-5,10,15-triazanonadecane (BE-4-4-4-4) inhibits etoposide cytotoxicity in U-251 MG (NCI) human brain tumor cells.",

abstract = "We studied whether pretreatment of U-251 MG human brain tumor cells with the polyamine analog 1,19-bis-(ethylamino)-5,10,15-triazanonadecane (BE-4-4-4-4) affected the cytotoxicity of the topoisomerase II inhibitor etoposide. We found that BE-4-4-4-4 protected cells from the cytotoxic effects of etoposide. Possible mechanisms for this protection may be related to enhanced DNA-nuclear matrix association in analog-treated cells.",

author = "Smirnov, {I. V.} and Feuerstein, {B. G.} and M. Pellarin and Marton, {L. J.} and Deen, {D. F.} and Basu, {H. S.}",

year = "1994",

month = nov,

language = "English (US)",

volume = "40",

pages = "975--980",

journal = "Cellular and molecular biology (Noisy-le-Grand, France)",

issn = "0145-5680",

publisher = "Cellular and Molecular Biology Association",

number = "7",

}

TY - JOUR

T1 - Pretreatment with the polyamine analog 1,19-bis-(ethylamino)-5,10,15-triazanonadecane (BE-4-4-4-4) inhibits etoposide cytotoxicity in U-251 MG (NCI) human brain tumor cells.

AU - Smirnov, I. V.

AU - Feuerstein, B. G.

AU - Pellarin, M.

AU - Marton, L. J.

AU - Deen, D. F.

AU - Basu, H. S.

PY - 1994/11

Y1 - 1994/11

N2 - We studied whether pretreatment of U-251 MG human brain tumor cells with the polyamine analog 1,19-bis-(ethylamino)-5,10,15-triazanonadecane (BE-4-4-4-4) affected the cytotoxicity of the topoisomerase II inhibitor etoposide. We found that BE-4-4-4-4 protected cells from the cytotoxic effects of etoposide. Possible mechanisms for this protection may be related to enhanced DNA-nuclear matrix association in analog-treated cells.

AB - We studied whether pretreatment of U-251 MG human brain tumor cells with the polyamine analog 1,19-bis-(ethylamino)-5,10,15-triazanonadecane (BE-4-4-4-4) affected the cytotoxicity of the topoisomerase II inhibitor etoposide. We found that BE-4-4-4-4 protected cells from the cytotoxic effects of etoposide. Possible mechanisms for this protection may be related to enhanced DNA-nuclear matrix association in analog-treated cells.

UR - http://www.scopus.com/inward/record.url?scp=0028540630&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0028540630&partnerID=8YFLogxK

M3 - Article

C2 - 7849564

AN - SCOPUS:0028540630

SN - 0145-5680

VL - 40

SP - 975

EP - 980

JO - Cellular and molecular biology (Noisy-le-Grand, France)

JF - Cellular and molecular biology (Noisy-le-Grand, France)

IS - 7

ER -

Pretreatment with the polyamine analog 1,19-bis-(ethylamino)-5,10,15-triazanonadecane (BE-4-4-4-4) inhibits etoposide cytotoxicity in U-251 MG (NCI) human brain tumor cells.

Abstract

ASJC Scopus subject areas

Other files and links

Fingerprint

Cite this