Pretreatment with a dopamine D1-receptor antagonist prevents metabolic activation by cocaine

William L. Thomas; Erick S. Cooke; Ronald P. Hammer

doi:10.1016/0304-3940(95)11865-T

Pretreatment with a dopamine D₁-receptor antagonist prevents metabolic activation by cocaine

William L. Thomas, Erick S. Cooke, Ronald P. Hammer

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

The pharmacological mechanism underlying metabolic activation of the rat extrapyramidal system by acute cocaine was examined using the quantitative 2-deoxyglucose autoradiographic method. Pretreatment with a selective dopamine D₁-like receptor antagonist, SCH 23390, prevented cocaine-induced metabolic activation in the entopeduncular nucleus and substantia nigra pars reticulata in a dose-dependent manner. These results suggest that activity in striatonigral circuits is induced by stimulation of D₁-like receptors by dopamine in the presence of acute cocaine.

Original language	English (US)
Pages (from-to)	161-164
Number of pages	4
Journal	Neuroscience Letters
Volume	196
Issue number	2
DOIs	https://doi.org/10.1016/0304-3940(95)11865-T
State	Published - Aug 25 1995
Externally published	Yes

Keywords

2-deoxyglucose
Cocaine
D-receptor
Striatum
Substantia nigra pars reticulata

ASJC Scopus subject areas

General Neuroscience

Access to Document

10.1016/0304-3940(95)11865-T

Cite this

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title = "Pretreatment with a dopamine D1-receptor antagonist prevents metabolic activation by cocaine",

abstract = "The pharmacological mechanism underlying metabolic activation of the rat extrapyramidal system by acute cocaine was examined using the quantitative 2-deoxyglucose autoradiographic method. Pretreatment with a selective dopamine D1-like receptor antagonist, SCH 23390, prevented cocaine-induced metabolic activation in the entopeduncular nucleus and substantia nigra pars reticulata in a dose-dependent manner. These results suggest that activity in striatonigral circuits is induced by stimulation of D1-like receptors by dopamine in the presence of acute cocaine.",

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AU - Cooke, Erick S.

AU - Hammer, Ronald P.

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N2 - The pharmacological mechanism underlying metabolic activation of the rat extrapyramidal system by acute cocaine was examined using the quantitative 2-deoxyglucose autoradiographic method. Pretreatment with a selective dopamine D1-like receptor antagonist, SCH 23390, prevented cocaine-induced metabolic activation in the entopeduncular nucleus and substantia nigra pars reticulata in a dose-dependent manner. These results suggest that activity in striatonigral circuits is induced by stimulation of D1-like receptors by dopamine in the presence of acute cocaine.

AB - The pharmacological mechanism underlying metabolic activation of the rat extrapyramidal system by acute cocaine was examined using the quantitative 2-deoxyglucose autoradiographic method. Pretreatment with a selective dopamine D1-like receptor antagonist, SCH 23390, prevented cocaine-induced metabolic activation in the entopeduncular nucleus and substantia nigra pars reticulata in a dose-dependent manner. These results suggest that activity in striatonigral circuits is induced by stimulation of D1-like receptors by dopamine in the presence of acute cocaine.

KW - 2-deoxyglucose

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KW - D-receptor

KW - Striatum

KW - Substantia nigra pars reticulata

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