TY - JOUR
T1 - Presence of Magnetic Resonance Imaging–Defined Inflammation Particularly in Overweight and Obese Women Increases Risk of Radiographic Knee Osteoarthritis
T2 - The POMA Study
AU - Roemer, Frank W.
AU - Guermazi, Ali
AU - Hannon, Michael J.
AU - Fujii, Tomoko
AU - Omoumi, Patrick
AU - Hunter, David J.
AU - Eckstein, Felix
AU - Kwoh, C. Kent
N1 - Funding Information:
This article was prepared using an Osteoarthritis Initiative (OAI) public‐use data set, and its contents do not necessarily reflect the opinions or views of the OAI Study Investigators, the NIH, or the private funding partners of the OAI. The OAI is a public–private partnership between the NIH (contracts N01‐AR‐2‐2258, N01‐AR‐2‐2259, N01‐AR‐2‐2260, N01‐AR‐2‐2261, and N01‐AR‐2‐2262) and private funding partners (Merck Research Laboratories, Novartis Pharmaceuticals, GlaxoSmithKline, and Pfizer, Inc.) and is conducted by the OAI Study Investigators. Private sector funding for the OAI is managed by the Foundation for the NIH. Dr. Hunter is principal investigator of the OAI/Foundation for the NIH Consortium Project, and Dr. Kwoh is principal investigator of an OAI site.
Funding Information:
The image analyses were funded by an NIH contract with the University of Pittsburgh (National Heart, Lung, and Blood Institute grant HHSN268201000021C; Pivotal Osteoarthritis Initiative Magnetic Resonance Imaging Analyses [POMA] contract) and in part by a vendor contract from the Osteoarthritis Initiative coordinating center at University of California, San Francisco (grant N01‐AR‐2‐2258). The statistical data analysis was funded by an NIH contract with the University of Pittsburgh (National Heart, Lung, and Blood Institute grant HHSN268201000021C; POMA contract).
Publisher Copyright:
© 2021 The Authors. Arthritis Care & Research published by Wiley Periodicals LLC on behalf of American College of Rheumatology.
PY - 2021
Y1 - 2021
N2 - Objective: The present study was undertaken to assess whether the odds for incident radiographic osteoarthritis (OA) differ between men and women in regard to body mass index (BMI) and inflammatory magnetic resonance imaging (MRI) markers 1 and 2 years prior, and whether the presence of inflammation on MRI differs between normal-weight and overweight/obese individuals who develop radiographic OA up to 4 years prior. Methods: We studied 355 knees from the Osteoarthritis Initiative study that developed incident radiographic OA and 355 matched controls. MRIs were read for effusion-synovitis and Hoffa-synovitis for up to 4 consecutive annual time points. Subjects were classified as normal-weight (BMI <25), overweight (BMI ≥25 and <30), or obese (BMI ≥30). Conditional logistic regression was used to assess odds of incident radiographic OA for effusion-synovitis and Hoffa-synovitis at 1 and 2 years prior to radiographic OA incidence (i.e., “P-1” and “P-2”) considering BMI category. Bivariate logistic regression was used to assess odds of inflammation for cases only. Results: One hundred seventy-eight (25.1%) participants were normal weight, 283 (39.9%) overweight, and 249 (35.1%) obese. At P-2, being overweight with Hoffa-synovitis, which had an odds ratio [OR] of 3.26 (95% confidence interval [95% CI] 1.39 −7.65), or effusion-synovitis (OR 3.56 [95% CI 1.45–8.75]) was associated with greater odds of incident radiographic OA in women. For those with incident radiographic OA, there were no increased odds of synovitis in the overweight/obese subgroup for most time points, but increased odds for effusion-synovitis were observed at P-2 (OR 2.21 [95% CI 1.11–4.43]). Conclusion: Presence of inflammatory markers seems to play a role especially in overweight women, while obese women have increased odds for radiographic OA also in the absence of these markers.
AB - Objective: The present study was undertaken to assess whether the odds for incident radiographic osteoarthritis (OA) differ between men and women in regard to body mass index (BMI) and inflammatory magnetic resonance imaging (MRI) markers 1 and 2 years prior, and whether the presence of inflammation on MRI differs between normal-weight and overweight/obese individuals who develop radiographic OA up to 4 years prior. Methods: We studied 355 knees from the Osteoarthritis Initiative study that developed incident radiographic OA and 355 matched controls. MRIs were read for effusion-synovitis and Hoffa-synovitis for up to 4 consecutive annual time points. Subjects were classified as normal-weight (BMI <25), overweight (BMI ≥25 and <30), or obese (BMI ≥30). Conditional logistic regression was used to assess odds of incident radiographic OA for effusion-synovitis and Hoffa-synovitis at 1 and 2 years prior to radiographic OA incidence (i.e., “P-1” and “P-2”) considering BMI category. Bivariate logistic regression was used to assess odds of inflammation for cases only. Results: One hundred seventy-eight (25.1%) participants were normal weight, 283 (39.9%) overweight, and 249 (35.1%) obese. At P-2, being overweight with Hoffa-synovitis, which had an odds ratio [OR] of 3.26 (95% confidence interval [95% CI] 1.39 −7.65), or effusion-synovitis (OR 3.56 [95% CI 1.45–8.75]) was associated with greater odds of incident radiographic OA in women. For those with incident radiographic OA, there were no increased odds of synovitis in the overweight/obese subgroup for most time points, but increased odds for effusion-synovitis were observed at P-2 (OR 2.21 [95% CI 1.11–4.43]). Conclusion: Presence of inflammatory markers seems to play a role especially in overweight women, while obese women have increased odds for radiographic OA also in the absence of these markers.
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U2 - 10.1002/acr.24568
DO - 10.1002/acr.24568
M3 - Article
C2 - 33527736
AN - SCOPUS:85106939550
JO - Arthritis Care and Research
JF - Arthritis Care and Research
SN - 2151-464X
ER -