TY - JOUR
T1 - Preoperative Therapy and Pancreatoduodenectomy for Pancreatic Ductal Adenocarcinoma
T2 - a 25-Year Single-Institution Experience
AU - Cloyd, Jordan M.
AU - Katz, Matthew H.G.
AU - Prakash, Laura
AU - Varadhachary, Gauri R.
AU - Wolff, Robert A.
AU - Shroff, Rachna T.
AU - Javle, Milind
AU - Fogelman, David
AU - Overman, Michael
AU - Crane, Christopher H.
AU - Koay, Eugene J.
AU - Das, Prajnan
AU - Krishnan, Sunil
AU - Minsky, Bruce D.
AU - Lee, Jeffrey H.
AU - Bhutani, Manoop S.
AU - Weston, Brian
AU - Ross, William
AU - Bhosale, Priya
AU - Tamm, Eric P.
AU - Wang, Huamin
AU - Maitra, Anirban
AU - Kim, Michael P.
AU - Aloia, Thomas A.
AU - Vauthey, Jean Nicholas
AU - Fleming, Jason B.
AU - Abbruzzese, James L.
AU - Pisters, Peter W.T.
AU - Evans, Douglas B.
AU - Lee, Jeffrey E.
N1 - Publisher Copyright:
© 2016, The Society for Surgery of the Alimentary Tract.
PY - 2017/1/1
Y1 - 2017/1/1
N2 - Background: The purpose of this study was to evaluate a single-institution experience with delivery of preoperative therapy to patients with pancreatic ductal adenocarcinoma (PDAC) prior to pancreatoduodenectomy (PD). Methods: Consecutive patients (622) with PDAC who underwent PD following chemotherapy and/or chemoradiation between 1990 and 2014 were retrospectively reviewed. Preoperative treatment regimens, clinicopathologic characteristics, operative details, and long-term outcomes in four successive time periods (1990–1999, 2000–2004, 2005–2009, 2010–2014) were evaluated and compared. Results: The average number of patients per year who underwent PD following preoperative therapy as well as the proportion of operations performed for borderline resectable and locally advanced (BR/LA) tumors increased over time. The use of induction systemic chemotherapy, as well as postoperative adjuvant chemotherapy, also increased over time. Throughout the study period, the mean EBL decreased while R0 margin rates and vascular resection rates increased overall. Despite the increase in BR/LA resections, locoregional recurrence (LR) rates remained similar over time, and overall survival (OS) improved significantly (median 24.1, 28.1, 37.3, 43.4 months, respectively, p < 0.0001). Conclusions: Despite increases in case complexity, relatively low rates of LR have been maintained while significant improvements in OS have been observed. Further improvements in patient outcomes will likely require disruptive advances in systemic therapy.
AB - Background: The purpose of this study was to evaluate a single-institution experience with delivery of preoperative therapy to patients with pancreatic ductal adenocarcinoma (PDAC) prior to pancreatoduodenectomy (PD). Methods: Consecutive patients (622) with PDAC who underwent PD following chemotherapy and/or chemoradiation between 1990 and 2014 were retrospectively reviewed. Preoperative treatment regimens, clinicopathologic characteristics, operative details, and long-term outcomes in four successive time periods (1990–1999, 2000–2004, 2005–2009, 2010–2014) were evaluated and compared. Results: The average number of patients per year who underwent PD following preoperative therapy as well as the proportion of operations performed for borderline resectable and locally advanced (BR/LA) tumors increased over time. The use of induction systemic chemotherapy, as well as postoperative adjuvant chemotherapy, also increased over time. Throughout the study period, the mean EBL decreased while R0 margin rates and vascular resection rates increased overall. Despite the increase in BR/LA resections, locoregional recurrence (LR) rates remained similar over time, and overall survival (OS) improved significantly (median 24.1, 28.1, 37.3, 43.4 months, respectively, p < 0.0001). Conclusions: Despite increases in case complexity, relatively low rates of LR have been maintained while significant improvements in OS have been observed. Further improvements in patient outcomes will likely require disruptive advances in systemic therapy.
KW - Neoadjuvant therapy
KW - Pancreatectomy
KW - Pancreatic ductal adenocarcinoma
KW - Pancreatoduodenectomy
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U2 - 10.1007/s11605-016-3265-1
DO - 10.1007/s11605-016-3265-1
M3 - Article
C2 - 27778257
AN - SCOPUS:84992223585
SN - 1091-255X
VL - 21
SP - 164
EP - 174
JO - Journal of Gastrointestinal Surgery
JF - Journal of Gastrointestinal Surgery
IS - 1
ER -