TY - GEN
T1 - Preliminary Investigation of Multiplexed Pinholes with Circular Apertures and Elliptical Ports for I-123 DAT Imaging
AU - Konik, Arda
AU - Fromme, Timothy
AU - Beenhouwer, Jan De
AU - He, Yulun
AU - Banerjee, Soumyanil
AU - Kalluri, Kesava
AU - Furenlid, Lars R.
AU - King, Michael A.
N1 - Funding Information:
Manuscript received November 8, 2017. This work was supported by the National of Biomedical Imaging and Bioengineering (NIBIB) Grant No. NIH R01-EB022092. The contents are solely the responsibility of the authors and do not necessarily represent the official views of the National Institutes of Health.
Publisher Copyright:
© 2017 IEEE.
PY - 2018/11/12
Y1 - 2018/11/12
N2 - Earlier, we proposed an inexpensive method to improve the performance of the conventional dual-head SPECT systems for I-123 dopamine transporter (DAT) imaging of Parkinson Disease. In this approach, the collimator on one head is replaced with a multi-pinhole (MPH) collimator while retaining the conventional collimator on the other head, thus enabling combined MPH/Parallelbeam (or Fanbeam) acquisition. The original MPH design consisted of 9 apertures with rectangular entrance/exit ports covering a cylindrical volume of interest (VOI) around the striatum with minimal multiplexing. Our main goal in this work is to increase the sensitivity of this system by adding more pinholes and allowing multiplexing. For a more efficient usage of the available detector coverage, we also proposed the usage of pinholes with circular apertures and elliptical ports referred to as 'lofthole' herein. Circular apertures are desired because of the uniform spatial resolution, more accurate point spread function modeling and fabrication while the elliptical ports provide more flexibility in the detector coverage compared to circular ports. In this preliminary work, we present a comparison of 9, 13, 17 and 16 pinhole configurations for conic-holes (circle bases) and loftholes (circular and elliptic bases) through projections obtained from GATE Monte Carlo software.
AB - Earlier, we proposed an inexpensive method to improve the performance of the conventional dual-head SPECT systems for I-123 dopamine transporter (DAT) imaging of Parkinson Disease. In this approach, the collimator on one head is replaced with a multi-pinhole (MPH) collimator while retaining the conventional collimator on the other head, thus enabling combined MPH/Parallelbeam (or Fanbeam) acquisition. The original MPH design consisted of 9 apertures with rectangular entrance/exit ports covering a cylindrical volume of interest (VOI) around the striatum with minimal multiplexing. Our main goal in this work is to increase the sensitivity of this system by adding more pinholes and allowing multiplexing. For a more efficient usage of the available detector coverage, we also proposed the usage of pinholes with circular apertures and elliptical ports referred to as 'lofthole' herein. Circular apertures are desired because of the uniform spatial resolution, more accurate point spread function modeling and fabrication while the elliptical ports provide more flexibility in the detector coverage compared to circular ports. In this preliminary work, we present a comparison of 9, 13, 17 and 16 pinhole configurations for conic-holes (circle bases) and loftholes (circular and elliptic bases) through projections obtained from GATE Monte Carlo software.
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U2 - 10.1109/NSSMIC.2017.8532608
DO - 10.1109/NSSMIC.2017.8532608
M3 - Conference contribution
AN - SCOPUS:85058460216
T3 - 2017 IEEE Nuclear Science Symposium and Medical Imaging Conference, NSS/MIC 2017 - Conference Proceedings
BT - 2017 IEEE Nuclear Science Symposium and Medical Imaging Conference, NSS/MIC 2017 - Conference Proceedings
PB - Institute of Electrical and Electronics Engineers Inc.
T2 - 2017 IEEE Nuclear Science Symposium and Medical Imaging Conference, NSS/MIC 2017
Y2 - 21 October 2017 through 28 October 2017
ER -