Prefrontal brain asymmetry and pre-menstrual dysphoric disorder symptomatology

Eynav E. Accortt; Jennifer L. Stewart; James A. Coan; Rachel Manber; John J.B. Allen

doi:10.1016/j.jad.2010.07.017

Prefrontal brain asymmetry and pre-menstrual dysphoric disorder symptomatology

Eynav E. Accortt, Jennifer L. Stewart, James A. Coan, Rachel Manber, John J.B. Allen

Research output: Contribution to journal › Article › peer-review

13 Scopus citations

Abstract

Background: Pre-menstrual dysphoric disorder (PMDD), a dysphoric form of pre-menstrual syndrome, is included as a diagnosis for further study in the DSM-IV-TR (APA, 2000). The present study investigated whether a marker of risk for major depressive disorder (MDD), prefrontal brain asymmetry, also characterizes women with PMDD. Methods: In a sample of 25 college women with PMDD symptomatology and 25 matched controls, resting frontal electroencephalographic (EEG) activity was assessed on four occasions within a two-week span. Results: Across several frontal sites women with PMDD had relatively less left than right prefrontal brain activity, consistent with a diathesis-stress model for menstrual-related dysphoria. Conclusions: The findings suggest an overlap in the risk profile for MDD and PMDD.

Original language	English (US)
Pages (from-to)	178-183
Number of pages	6
Journal	Journal of Affective Disorders
Volume	128
Issue number	1-2
DOIs	https://doi.org/10.1016/j.jad.2010.07.017
State	Published - Jan 2011

Keywords

Diathesis
EEG asymmetry
Pre-menstrual dysphoria
Risk

ASJC Scopus subject areas

Clinical Psychology
Psychiatry and Mental health

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10.1016/j.jad.2010.07.017

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title = "Prefrontal brain asymmetry and pre-menstrual dysphoric disorder symptomatology",

abstract = "Background: Pre-menstrual dysphoric disorder (PMDD), a dysphoric form of pre-menstrual syndrome, is included as a diagnosis for further study in the DSM-IV-TR (APA, 2000). The present study investigated whether a marker of risk for major depressive disorder (MDD), prefrontal brain asymmetry, also characterizes women with PMDD. Methods: In a sample of 25 college women with PMDD symptomatology and 25 matched controls, resting frontal electroencephalographic (EEG) activity was assessed on four occasions within a two-week span. Results: Across several frontal sites women with PMDD had relatively less left than right prefrontal brain activity, consistent with a diathesis-stress model for menstrual-related dysphoria. Conclusions: The findings suggest an overlap in the risk profile for MDD and PMDD.",

keywords = "Diathesis, EEG asymmetry, Pre-menstrual dysphoria, Risk",

author = "Accortt, {Eynav E.} and Stewart, {Jennifer L.} and Coan, {James A.} and Rachel Manber and Allen, {John J.B.}",

note = "Funding Information: This research was supported in part by grants from the National Institutes of Health ( R01-MH066902 ) and the National Alliance for Research on Schizophrenia and Depression (NARSAD) to John Allen. The authors wish to thank Eliza Fergerson, Jamie Velo, Dara Halpern, Craig Santerre, Amanda Brody, Jay Hegde and myriad research assistants for their help on this project.",

year = "2011",

month = jan,

doi = "10.1016/j.jad.2010.07.017",

language = "English (US)",

volume = "128",

pages = "178--183",

journal = "Journal of Affective Disorders",

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AU - Accortt, Eynav E.

AU - Stewart, Jennifer L.

AU - Coan, James A.

AU - Manber, Rachel

AU - Allen, John J.B.

N1 - Funding Information: This research was supported in part by grants from the National Institutes of Health ( R01-MH066902 ) and the National Alliance for Research on Schizophrenia and Depression (NARSAD) to John Allen. The authors wish to thank Eliza Fergerson, Jamie Velo, Dara Halpern, Craig Santerre, Amanda Brody, Jay Hegde and myriad research assistants for their help on this project.

PY - 2011/1

Y1 - 2011/1

N2 - Background: Pre-menstrual dysphoric disorder (PMDD), a dysphoric form of pre-menstrual syndrome, is included as a diagnosis for further study in the DSM-IV-TR (APA, 2000). The present study investigated whether a marker of risk for major depressive disorder (MDD), prefrontal brain asymmetry, also characterizes women with PMDD. Methods: In a sample of 25 college women with PMDD symptomatology and 25 matched controls, resting frontal electroencephalographic (EEG) activity was assessed on four occasions within a two-week span. Results: Across several frontal sites women with PMDD had relatively less left than right prefrontal brain activity, consistent with a diathesis-stress model for menstrual-related dysphoria. Conclusions: The findings suggest an overlap in the risk profile for MDD and PMDD.

AB - Background: Pre-menstrual dysphoric disorder (PMDD), a dysphoric form of pre-menstrual syndrome, is included as a diagnosis for further study in the DSM-IV-TR (APA, 2000). The present study investigated whether a marker of risk for major depressive disorder (MDD), prefrontal brain asymmetry, also characterizes women with PMDD. Methods: In a sample of 25 college women with PMDD symptomatology and 25 matched controls, resting frontal electroencephalographic (EEG) activity was assessed on four occasions within a two-week span. Results: Across several frontal sites women with PMDD had relatively less left than right prefrontal brain activity, consistent with a diathesis-stress model for menstrual-related dysphoria. Conclusions: The findings suggest an overlap in the risk profile for MDD and PMDD.

KW - Diathesis

KW - EEG asymmetry

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KW - Risk

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Prefrontal brain asymmetry and pre-menstrual dysphoric disorder symptomatology

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Keywords

ASJC Scopus subject areas

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