Prefrontal brain asymmetry and pre-menstrual dysphoric disorder symptomatology

Eynav E. Accortt, Jennifer L. Stewart, James A. Coan, Rachel Manber, John J.B. Allen

Research output: Contribution to journalArticlepeer-review

13 Scopus citations


Background: Pre-menstrual dysphoric disorder (PMDD), a dysphoric form of pre-menstrual syndrome, is included as a diagnosis for further study in the DSM-IV-TR (APA, 2000). The present study investigated whether a marker of risk for major depressive disorder (MDD), prefrontal brain asymmetry, also characterizes women with PMDD. Methods: In a sample of 25 college women with PMDD symptomatology and 25 matched controls, resting frontal electroencephalographic (EEG) activity was assessed on four occasions within a two-week span. Results: Across several frontal sites women with PMDD had relatively less left than right prefrontal brain activity, consistent with a diathesis-stress model for menstrual-related dysphoria. Conclusions: The findings suggest an overlap in the risk profile for MDD and PMDD.

Original languageEnglish (US)
Pages (from-to)178-183
Number of pages6
JournalJournal of Affective Disorders
Issue number1-2
StatePublished - Jan 2011


  • Diathesis
  • EEG asymmetry
  • Pre-menstrual dysphoria
  • Risk

ASJC Scopus subject areas

  • Clinical Psychology
  • Psychiatry and Mental health


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