TY - JOUR
T1 - Prefrontal brain asymmetry and pre-menstrual dysphoric disorder symptomatology
AU - Accortt, Eynav E.
AU - Stewart, Jennifer L.
AU - Coan, James A.
AU - Manber, Rachel
AU - Allen, John J.B.
N1 - Funding Information:
This research was supported in part by grants from the National Institutes of Health ( R01-MH066902 ) and the National Alliance for Research on Schizophrenia and Depression (NARSAD) to John Allen. The authors wish to thank Eliza Fergerson, Jamie Velo, Dara Halpern, Craig Santerre, Amanda Brody, Jay Hegde and myriad research assistants for their help on this project.
PY - 2011/1
Y1 - 2011/1
N2 - Background: Pre-menstrual dysphoric disorder (PMDD), a dysphoric form of pre-menstrual syndrome, is included as a diagnosis for further study in the DSM-IV-TR (APA, 2000). The present study investigated whether a marker of risk for major depressive disorder (MDD), prefrontal brain asymmetry, also characterizes women with PMDD. Methods: In a sample of 25 college women with PMDD symptomatology and 25 matched controls, resting frontal electroencephalographic (EEG) activity was assessed on four occasions within a two-week span. Results: Across several frontal sites women with PMDD had relatively less left than right prefrontal brain activity, consistent with a diathesis-stress model for menstrual-related dysphoria. Conclusions: The findings suggest an overlap in the risk profile for MDD and PMDD.
AB - Background: Pre-menstrual dysphoric disorder (PMDD), a dysphoric form of pre-menstrual syndrome, is included as a diagnosis for further study in the DSM-IV-TR (APA, 2000). The present study investigated whether a marker of risk for major depressive disorder (MDD), prefrontal brain asymmetry, also characterizes women with PMDD. Methods: In a sample of 25 college women with PMDD symptomatology and 25 matched controls, resting frontal electroencephalographic (EEG) activity was assessed on four occasions within a two-week span. Results: Across several frontal sites women with PMDD had relatively less left than right prefrontal brain activity, consistent with a diathesis-stress model for menstrual-related dysphoria. Conclusions: The findings suggest an overlap in the risk profile for MDD and PMDD.
KW - Diathesis
KW - EEG asymmetry
KW - Pre-menstrual dysphoria
KW - Risk
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U2 - 10.1016/j.jad.2010.07.017
DO - 10.1016/j.jad.2010.07.017
M3 - Article
C2 - 20833433
AN - SCOPUS:78649661557
VL - 128
SP - 178
EP - 183
JO - Journal of Affective Disorders
JF - Journal of Affective Disorders
SN - 0165-0327
IS - 1-2
ER -