@article{1ad74c7279d54127a054cd8a3797a8bc,
title = "Predictive model for plasma concentration-versus-time profiles of investigational anticancer drugs in patientsi",
abstract = "We report a model that provides a strong correlation between mouse toxicity data [mouse lethal dose 10% (LD10)] and human plasma concentration-versus-time (CXT) data for 22 commonly used anticancer agents. Mouse toxicity data (LD10) from two dosing schedules, daily times one and daily times seven, were evaluated for the two mouse strains BDF/1 and Swiss. Data from BDF/1 mice were selected for analysis because they were more abundant. Strong correlations were found between LD10 and human plasma CXT data for both daily times one and daily times seven dosing schedules-In (CXT) = -1.6504 + [0.8408 × In (LD10)], r = .84, P < .0001, and In (CXT) = -0.0754 + [0.8954 × In (LD10)], r = .90, P < .0001, respectively. These correlations may serve as useful models to predict the maximally tolerated dose of an investigational anticancer agent prior to entry into clinical trials and to assist in the selection of clinically relevant in vitro CXTs for new-agent screening against human tumors.",
author = "Davis, {Lisa E.} and Alberts, {David S.} and Plezia, {Patricia M.} and Roe, {Denise J.} and Griswold, {Daniel P.}",
note = "Funding Information: 'Received October 14, 1987; revised May 17, 1988; accepted May 20, 1988. Supported by Public Health Service grants CA-17094 and CA-23024 from the National Cancer Institute, National Institutes of Health, Department of Health and Human Services; by the American Society of Hospital Pharmacists Research and Education Foundation; -<nd by a donation from the Phi Beta Psi National Sorority. 'Pharmacology Research Program, Arizona Cancer Center, College of Medicine, University of Arizona, Tucson, AZ. 4Department of Pharmacy Practice, College of Pharmacy, University of Arizona, Tucson, AZ. 'Department of Medicine, College of Medicine, University of Arizona, Tucson, AZ 'Department of Pharmacology, College of Medicine, University of Arizona, Tucson, AZ. 'Southern Research Institute, Birmingham, AL. 'We thank Drs; Robert Dorr, William Dalton, and Sydney Salmon for scientific advice. *Correspondence to: Dr. David S. Alberts, Arizona Cancer Center, 1515 N. Campbell Ave., Tucson, AZ 85724.",
year = "1988",
month = aug,
day = "3",
doi = "10.1093/jnci/80.11.815",
language = "English (US)",
volume = "80",
pages = "815--819",
journal = "Journal of the National Cancer Institute",
issn = "0027-8874",
publisher = "Oxford University Press",
number = "11",
}