Prediction of Setschenow constants

Nina Ni; Samuel H. Yalkowsky

doi:10.1016/S0378-5173(03)00008-5

Prediction of Setschenow constants

Nina Ni, Samuel H. Yalkowsky

Pharmacology and Toxicology

Research output: Contribution to journal › Article › peer-review

100 Scopus citations

Abstract

The Setschenow (salting out) constant by sodium chloride is related to molar volume, aqueous solubility, and octanol-water partition coefficient, K_ow, of the drug solute. This study validates a previously proposed relationship between the salting out constant of a solute and its partition coefficient. It also shows that the partition coefficient is a better descriptor of salting out than either molar volume or solubility.

Original language	English (US)
Pages (from-to)	167-172
Number of pages	6
Journal	International Journal of Pharmaceutics
Volume	254
Issue number	2
DOIs	https://doi.org/10.1016/S0378-5173(03)00008-5
State	Published - Mar 26 2003

Keywords

Intrinsic solubility
Le Bas volume
Partition coefficient
Setschenow constant

ASJC Scopus subject areas

Pharmaceutical Science

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10.1016/S0378-5173(03)00008-5

Cite this

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abstract = "The Setschenow (salting out) constant by sodium chloride is related to molar volume, aqueous solubility, and octanol-water partition coefficient, Kow, of the drug solute. This study validates a previously proposed relationship between the salting out constant of a solute and its partition coefficient. It also shows that the partition coefficient is a better descriptor of salting out than either molar volume or solubility.",

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T1 - Prediction of Setschenow constants

AU - Ni, Nina

AU - Yalkowsky, Samuel H.

PY - 2003/3/26

Y1 - 2003/3/26

N2 - The Setschenow (salting out) constant by sodium chloride is related to molar volume, aqueous solubility, and octanol-water partition coefficient, Kow, of the drug solute. This study validates a previously proposed relationship between the salting out constant of a solute and its partition coefficient. It also shows that the partition coefficient is a better descriptor of salting out than either molar volume or solubility.

AB - The Setschenow (salting out) constant by sodium chloride is related to molar volume, aqueous solubility, and octanol-water partition coefficient, Kow, of the drug solute. This study validates a previously proposed relationship between the salting out constant of a solute and its partition coefficient. It also shows that the partition coefficient is a better descriptor of salting out than either molar volume or solubility.

KW - Intrinsic solubility

KW - Le Bas volume

KW - Partition coefficient

KW - Setschenow constant

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U2 - 10.1016/S0378-5173(03)00008-5

DO - 10.1016/S0378-5173(03)00008-5

M3 - Article

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SN - 0378-5173

VL - 254

SP - 167

EP - 172

JO - International Journal of Pharmaceutics

JF - International Journal of Pharmaceutics

IS - 2

ER -

Prediction of Setschenow constants

Abstract

Keywords

ASJC Scopus subject areas

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