Preclinical models for chemoprevention of colon cancer.

Eugene W. Gerner, Natalia Ignatenko, David G. Besselsen

Research output: Contribution to journalReview articlepeer-review

9 Scopus citations


Colon cancer is the second leading cause of cancer incidence and death in the USA in 2002. Specific genetic defects have been identified which cause hereditary colon cancers in humans. In addition, a number of intestinal luminal risk factors for colon cancer have been described. This information has been exploited to develop experimental cell and rodent models which recapitulate features of human colon cancer. In this chapter, we will discuss the strengths and limitations of these models to further our understanding of basic mechanisms of colon carcinogenesis and to develop strategies for colon cancer chemoprevention.

Original languageEnglish (US)
Pages (from-to)58-71; discussion 264-266
JournalRecent results in cancer research. Fortschritte der Krebsforschung. Progrès dans les recherches sur le cancer
StatePublished - 2003

ASJC Scopus subject areas

  • Oncology
  • Cancer Research


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