Preclinical models for chemoprevention of colon cancer.

Eugene W. Gerner; Natalia Ignatenko; David G. Besselsen

doi:10.1007/978-3-642-55647-0_6

Preclinical models for chemoprevention of colon cancer.

Eugene W. Gerner, Natalia Ignatenko, David G. Besselsen

University Animal Care

Research output: Contribution to journal › Review article › peer-review

9 Scopus citations

Abstract

Colon cancer is the second leading cause of cancer incidence and death in the USA in 2002. Specific genetic defects have been identified which cause hereditary colon cancers in humans. In addition, a number of intestinal luminal risk factors for colon cancer have been described. This information has been exploited to develop experimental cell and rodent models which recapitulate features of human colon cancer. In this chapter, we will discuss the strengths and limitations of these models to further our understanding of basic mechanisms of colon carcinogenesis and to develop strategies for colon cancer chemoprevention.

Original language	English (US)
Pages (from-to)	58-71; discussion 264-266
Journal	Recent results in cancer research. Fortschritte der Krebsforschung. Progrès dans les recherches sur le cancer
Volume	163
DOIs	https://doi.org/10.1007/978-3-642-55647-0_6
State	Published - 2003

ASJC Scopus subject areas

Oncology
Cancer Research

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10.1007/978-3-642-55647-0_6

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AU - Ignatenko, Natalia

AU - Besselsen, David G.

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AB - Colon cancer is the second leading cause of cancer incidence and death in the USA in 2002. Specific genetic defects have been identified which cause hereditary colon cancers in humans. In addition, a number of intestinal luminal risk factors for colon cancer have been described. This information has been exploited to develop experimental cell and rodent models which recapitulate features of human colon cancer. In this chapter, we will discuss the strengths and limitations of these models to further our understanding of basic mechanisms of colon carcinogenesis and to develop strategies for colon cancer chemoprevention.

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JO - Recent results in cancer research. Fortschritte der Krebsforschung. Progrès dans les recherches sur le cancer

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Preclinical models for chemoprevention of colon cancer.

Abstract

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