Precision Genomic Medicine in Cystic Fibrosis

Eugene H. Chang, Joseph Zabner

Research output: Contribution to journalArticlepeer-review

21 Scopus citations

Abstract

The successful application of precision genomic medicine requires an understanding of how a person's genome can influence his or her disease phenotype and how medical therapies can provide personalized therapy to one's genotype. In this review, we highlight advances in precision genomic medicine in cystic fibrosis (CF), a classic autosomal recessive genetic disorder. We discuss genotype-phenotype correlations in CF, genetic and environmental modifiers of disease, and pharmacogenetic therapies that target specific genetic mutations thereby addressing the primary defect of cystic fibrosis.

Original languageEnglish (US)
Pages (from-to)606-610
Number of pages5
JournalClinical and Translational Science
Volume8
Issue number5
DOIs
StatePublished - Oct 2015
Externally publishedYes

Keywords

  • Epithelium
  • Genes
  • Genetics

ASJC Scopus subject areas

  • Neuroscience(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)

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