Practical pd(TFA)2-catalyzed aerobic [4+1] annulation for the synthesis of pyrroles via “one-pot” cascade reactions

Yang Yu, Zhiguo Mang, Wei Yang, Hao Li, Wei Wang

Research output: Contribution to journalArticlepeer-review

5 Scopus citations

Abstract

The Pd(TFA)2-catalyzed [4+1] annulation of chained or cyclic α-alkenyl-dicarbonyl compounds and unprotected primary amines for “one-pot” synthesis of pyrroles is reported here. Enamination and amino-alkene were involved in this practical and efficient tandem reaction. The annulation products were isolated in moderate to excellent yields with O2 as the terminal oxidant under mild conditions. In addition, this method was applied to synthesize highly regioselective aminomethylated and di(1H-pyrrol-3-yl)methane products.

Original languageEnglish (US)
Article number169
JournalCatalysts
Volume6
Issue number11
DOIs
StatePublished - Nov 2016
Externally publishedYes

Keywords

  • One-pot
  • Pd(TFA)
  • Regio-selective
  • Tandem reaction
  • Unprotected primary amines
  • [4+1] annulation
  • α-alkenyl-dicarbonyl compounds

ASJC Scopus subject areas

  • Catalysis
  • Physical and Theoretical Chemistry

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