Practical application of DaTQUANT with optimal threshold for diagnostic accuracy of dopamine transporter SPECT

Matthew Neill, Julia M. Fisher, Christine Brand, Hong Lei, Scott J. Sherman, Ying Hui Chou, Phillip H. Kuo

Research output: Contribution to journalArticlepeer-review

6 Scopus citations


Evaluation of Parkinsonian Syndromes (PS) with Ioflupane iodine-123 dopamine transporter single photon emission computed tomography (DaT-SPECT), in conjunction with history and clinical examination, aids in diagnosis. FDA-approved, semi-quantitative software, DaTQUANT™ (GE Healthcare, Chicago, IL, USA) is available to assist in interpretation. This study aims to evaluate the optimal variables and thresholds of DaTQUANT to yield the optimal diagnostic accuracy. It is a retrospective review with three different patient populations. DaT-SPECT images from all three study groups were evaluated using DaTQUANT™ software, and both single and multi-variable logistic regression were used to model PS status. The optimal models were chosen via accuracy, sensitivity, and specificity, then evaluated on the other study groups. Among single variable models, the posterior putamen yielded the highest accuracy (84% to 95%), while balancing sensitivity and specificity. Multi-variable models did not substantially improve the accuracy. When the optimal single variable models for each group were used to evaluate the remaining two groups, comparable results were achieved. In typical utilization of DaT-SPECT for differentiation between nigrostriatal degenerative disease (NSDD) and non-NSDD, the posterior putamen was the single variable that yielded the highest accuracy across three different patient populations. The posterior putamen’s recommended thresholds for DaTQUANT are SBR ≤ 1.0, z-score of ≤−1.8 and percent deviation ≤ −0.34.

Original languageEnglish (US)
Pages (from-to)980-989
Number of pages10
Issue number4
StatePublished - Dec 2021


  • FP-CiT
  • Ioflupane
  • Parkinson
  • Quantification

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging


Dive into the research topics of 'Practical application of DaTQUANT with optimal threshold for diagnostic accuracy of dopamine transporter SPECT'. Together they form a unique fingerprint.

Cite this