Potential of block copolymer- and immuno-conjugates for tumor-targeted delivery of Bowman-Birk soybean proteinase inhibitor

I. P. Gladysheva; O. V. Polekhina; T. A. Karmakova; E. R. Nemtsova; R. I. Yakubovskaya; W. C. Shen; A. R. Kennedy; N. I. Larionova

doi:10.1016/S0168-3659(01)00337-6

Potential of block copolymer- and immuno-conjugates for tumor-targeted delivery of Bowman-Birk soybean proteinase inhibitor

I. P. Gladysheva, O. V. Polekhina, T. A. Karmakova, E. R. Nemtsova, R. I. Yakubovskaya, W. C. Shen, A. R. Kennedy, N. I. Larionova

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

The present work reports the effect of conjugation of the anticarcinogenic and antitumor soybean Bowman-Birk protease inhibitor (BBI) with amphiphilic block copolymer of ethylene oxide and propylene oxide (PEO-PPO) as well as with monoclonal antibody via clinical dextran (D) on tumor-targeted delivery of BBI.

Original language	English (US)
Pages (from-to)	303-308
Number of pages	6
Journal	Journal of Controlled Release
Volume	74
Issue number	1-3
DOIs	https://doi.org/10.1016/S0168-3659(01)00337-6
State	Published - Jul 6 2001
Externally published	Yes

Keywords

Ethylene oxide and propylene oxide block copolymer
Immunoconjugate
Soybean Bowman-Birk protease inhibitor (BBI)
Targeting
Tumor

ASJC Scopus subject areas

Pharmaceutical Science

Access to Document

10.1016/S0168-3659(01)00337-6

Cite this

Potential of block copolymer- and immuno-conjugates for tumor-targeted delivery of Bowman-Birk soybean proteinase inhibitor. / Gladysheva, I. P.; Polekhina, O. V.; Karmakova, T. A.; Nemtsova, E. R.; Yakubovskaya, R. I.; Shen, W. C.; Kennedy, A. R.; Larionova, N. I.

In: Journal of Controlled Release, Vol. 74, No. 1-3, 06.07.2001, p. 303-308.

Research output: Contribution to journal › Article › peer-review

@article{1bb8028bac1b4be8aa6faafaea4dab63,

title = "Potential of block copolymer- and immuno-conjugates for tumor-targeted delivery of Bowman-Birk soybean proteinase inhibitor",

abstract = "The present work reports the effect of conjugation of the anticarcinogenic and antitumor soybean Bowman-Birk protease inhibitor (BBI) with amphiphilic block copolymer of ethylene oxide and propylene oxide (PEO-PPO) as well as with monoclonal antibody via clinical dextran (D) on tumor-targeted delivery of BBI.",

keywords = "Ethylene oxide and propylene oxide block copolymer, Immunoconjugate, Soybean Bowman-Birk protease inhibitor (BBI), Targeting, Tumor",

author = "Gladysheva, {I. P.} and Polekhina, {O. V.} and Karmakova, {T. A.} and Nemtsova, {E. R.} and Yakubovskaya, {R. I.} and Shen, {W. C.} and Kennedy, {A. R.} and Larionova, {N. I.}",

note = "Funding Information: This work was partially supported by a grant from the Russian State Research Program {\textquoteleft}The Newest Methods of Bioengineering{\textquoteright}, sub-programme {\textquoteleft}Engineering in Enzymology{\textquoteright}.",

year = "2001",

month = jul,

day = "6",

doi = "10.1016/S0168-3659(01)00337-6",

language = "English (US)",

volume = "74",

pages = "303--308",

journal = "Journal of Controlled Release",

issn = "0168-3659",

publisher = "Elsevier",

number = "1-3",

}

TY - JOUR

T1 - Potential of block copolymer- and immuno-conjugates for tumor-targeted delivery of Bowman-Birk soybean proteinase inhibitor

AU - Gladysheva, I. P.

AU - Polekhina, O. V.

AU - Karmakova, T. A.

AU - Nemtsova, E. R.

AU - Yakubovskaya, R. I.

AU - Shen, W. C.

AU - Kennedy, A. R.

AU - Larionova, N. I.

N1 - Funding Information: This work was partially supported by a grant from the Russian State Research Program ‘The Newest Methods of Bioengineering’, sub-programme ‘Engineering in Enzymology’.

PY - 2001/7/6

Y1 - 2001/7/6

N2 - The present work reports the effect of conjugation of the anticarcinogenic and antitumor soybean Bowman-Birk protease inhibitor (BBI) with amphiphilic block copolymer of ethylene oxide and propylene oxide (PEO-PPO) as well as with monoclonal antibody via clinical dextran (D) on tumor-targeted delivery of BBI.

AB - The present work reports the effect of conjugation of the anticarcinogenic and antitumor soybean Bowman-Birk protease inhibitor (BBI) with amphiphilic block copolymer of ethylene oxide and propylene oxide (PEO-PPO) as well as with monoclonal antibody via clinical dextran (D) on tumor-targeted delivery of BBI.

KW - Ethylene oxide and propylene oxide block copolymer

KW - Immunoconjugate

KW - Soybean Bowman-Birk protease inhibitor (BBI)

KW - Targeting

KW - Tumor

UR - http://www.scopus.com/inward/record.url?scp=0035816189&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0035816189&partnerID=8YFLogxK

U2 - 10.1016/S0168-3659(01)00337-6

DO - 10.1016/S0168-3659(01)00337-6

M3 - Article

C2 - 11489510

AN - SCOPUS:0035816189

VL - 74

SP - 303

EP - 308

JO - Journal of Controlled Release

JF - Journal of Controlled Release

SN - 0168-3659

IS - 1-3

ER -

Potential of block copolymer- and immuno-conjugates for tumor-targeted delivery of Bowman-Birk soybean proteinase inhibitor

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this