Potential of block copolymer- and immuno-conjugates for tumor-targeted delivery of Bowman-Birk soybean proteinase inhibitor

I. P. Gladysheva, O. V. Polekhina, T. A. Karmakova, E. R. Nemtsova, R. I. Yakubovskaya, W. C. Shen, A. R. Kennedy, N. I. Larionova

Research output: Contribution to journalArticlepeer-review

6 Scopus citations

Abstract

The present work reports the effect of conjugation of the anticarcinogenic and antitumor soybean Bowman-Birk protease inhibitor (BBI) with amphiphilic block copolymer of ethylene oxide and propylene oxide (PEO-PPO) as well as with monoclonal antibody via clinical dextran (D) on tumor-targeted delivery of BBI.

Original languageEnglish (US)
Pages (from-to)303-308
Number of pages6
JournalJournal of Controlled Release
Volume74
Issue number1-3
DOIs
StatePublished - Jul 6 2001
Externally publishedYes

Keywords

  • Ethylene oxide and propylene oxide block copolymer
  • Immunoconjugate
  • Soybean Bowman-Birk protease inhibitor (BBI)
  • Targeting
  • Tumor

ASJC Scopus subject areas

  • Pharmaceutical Science

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