Postovariectomy weight gain in female rats is reversed by estrogen receptor α agonist, propylpyrazoletriol

Iga N. Wegorzewska; Katy Walters; Michael J. Weiser; Danette F. Cruthirds; Emily Ewell; Darwin O. Larco; Robert J. Handa; T. John Wu

doi:10.1016/j.ajog.2007.11.054

Postovariectomy weight gain in female rats is reversed by estrogen receptor α agonist, propylpyrazoletriol

Iga N. Wegorzewska, Katy Walters, Michael J. Weiser, Danette F. Cruthirds, Emily Ewell, Darwin O. Larco, Robert J. Handa, T. John Wu

Basic Medical Sciences, Phoenix

Research output: Contribution to journal › Article › peer-review

45 Scopus citations

Abstract

Objective: The objective of this study was to distinguish the role of specific estrogen receptors (ERs), ERα and ERβ, on body weight regulation using a rat model of weight gain subsequent to menopause. Study Design: Ovariectomized rats were utilized as the animal model to simulate the postmenopause weight gain. The rats were ovariectomized and subcutaneously injected daily with vehicle, estradiol-17β (E2), propylpyrazoletriol (PPT; ERα agonist) and diarylpropionitrile (DPN; ERβ agonist). To further control for the possible effect of estrogen secreted from adrenals, a second experiment was conducted during which the rats were adrenalectomized and ovariectomized. Results: Ovariectomy significantly increased (P < .05) body weight, whereas treatment of ovariectomized rats with E2 and PPT, but DPN decreased (P < .05) body weight. The results from the second study with ovariectomized/adrenalectomized rats were consistent with the first experiment. Conclusion: These results suggest that the activation of ERα is important in regulating body weight.

Original language	English (US)
Pages (from-to)	67.e1-67.e5
Journal	American journal of obstetrics and gynecology
Volume	199
Issue number	1
DOIs	https://doi.org/10.1016/j.ajog.2007.11.054
State	Published - Jul 2008

Keywords

adrenalectomy
body weight
menopause
ovariectomy
rat
specific estrogen receptor modulators

ASJC Scopus subject areas

Obstetrics and Gynecology

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10.1016/j.ajog.2007.11.054

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title = "Postovariectomy weight gain in female rats is reversed by estrogen receptor α agonist, propylpyrazoletriol",

abstract = "Objective: The objective of this study was to distinguish the role of specific estrogen receptors (ERs), ERα and ERβ, on body weight regulation using a rat model of weight gain subsequent to menopause. Study Design: Ovariectomized rats were utilized as the animal model to simulate the postmenopause weight gain. The rats were ovariectomized and subcutaneously injected daily with vehicle, estradiol-17β (E2), propylpyrazoletriol (PPT; ERα agonist) and diarylpropionitrile (DPN; ERβ agonist). To further control for the possible effect of estrogen secreted from adrenals, a second experiment was conducted during which the rats were adrenalectomized and ovariectomized. Results: Ovariectomy significantly increased (P < .05) body weight, whereas treatment of ovariectomized rats with E2 and PPT, but DPN decreased (P < .05) body weight. The results from the second study with ovariectomized/adrenalectomized rats were consistent with the first experiment. Conclusion: These results suggest that the activation of ERα is important in regulating body weight.",

keywords = "adrenalectomy, body weight, menopause, ovariectomy, rat, specific estrogen receptor modulators",

author = "Wegorzewska, {Iga N.} and Katy Walters and Weiser, {Michael J.} and Cruthirds, {Danette F.} and Emily Ewell and Larco, {Darwin O.} and Handa, {Robert J.} and Wu, {T. John}",

note = "Funding Information: This study was supported by US Department of Defense Grant H085BL (to T.J.W.); US Department of Defense Grant USAMRMC-04182001 (to T.J.W. and R.J.H.); and National Institutes of Health Grant NS039951 (to R.J.H.). ",

year = "2008",

month = jul,

doi = "10.1016/j.ajog.2007.11.054",

language = "English (US)",

volume = "199",

pages = "67.e1--67.e5",

journal = "American journal of obstetrics and gynecology",

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TY - JOUR

T1 - Postovariectomy weight gain in female rats is reversed by estrogen receptor α agonist, propylpyrazoletriol

AU - Wegorzewska, Iga N.

AU - Walters, Katy

AU - Weiser, Michael J.

AU - Cruthirds, Danette F.

AU - Ewell, Emily

AU - Larco, Darwin O.

AU - Handa, Robert J.

AU - Wu, T. John

N1 - Funding Information: This study was supported by US Department of Defense Grant H085BL (to T.J.W.); US Department of Defense Grant USAMRMC-04182001 (to T.J.W. and R.J.H.); and National Institutes of Health Grant NS039951 (to R.J.H.).

PY - 2008/7

Y1 - 2008/7

N2 - Objective: The objective of this study was to distinguish the role of specific estrogen receptors (ERs), ERα and ERβ, on body weight regulation using a rat model of weight gain subsequent to menopause. Study Design: Ovariectomized rats were utilized as the animal model to simulate the postmenopause weight gain. The rats were ovariectomized and subcutaneously injected daily with vehicle, estradiol-17β (E2), propylpyrazoletriol (PPT; ERα agonist) and diarylpropionitrile (DPN; ERβ agonist). To further control for the possible effect of estrogen secreted from adrenals, a second experiment was conducted during which the rats were adrenalectomized and ovariectomized. Results: Ovariectomy significantly increased (P < .05) body weight, whereas treatment of ovariectomized rats with E2 and PPT, but DPN decreased (P < .05) body weight. The results from the second study with ovariectomized/adrenalectomized rats were consistent with the first experiment. Conclusion: These results suggest that the activation of ERα is important in regulating body weight.

AB - Objective: The objective of this study was to distinguish the role of specific estrogen receptors (ERs), ERα and ERβ, on body weight regulation using a rat model of weight gain subsequent to menopause. Study Design: Ovariectomized rats were utilized as the animal model to simulate the postmenopause weight gain. The rats were ovariectomized and subcutaneously injected daily with vehicle, estradiol-17β (E2), propylpyrazoletriol (PPT; ERα agonist) and diarylpropionitrile (DPN; ERβ agonist). To further control for the possible effect of estrogen secreted from adrenals, a second experiment was conducted during which the rats were adrenalectomized and ovariectomized. Results: Ovariectomy significantly increased (P < .05) body weight, whereas treatment of ovariectomized rats with E2 and PPT, but DPN decreased (P < .05) body weight. The results from the second study with ovariectomized/adrenalectomized rats were consistent with the first experiment. Conclusion: These results suggest that the activation of ERα is important in regulating body weight.

KW - adrenalectomy

KW - body weight

KW - menopause

KW - ovariectomy

KW - rat

KW - specific estrogen receptor modulators

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ER -

Postovariectomy weight gain in female rats is reversed by estrogen receptor α agonist, propylpyrazoletriol

Abstract

Keywords

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