Post-acute psychological effects of classical serotonergic psychedelics: A systematic review and meta-analysis

Simon B. Goldberg, Benjamin Shechet, Christopher R. Nicholas, Chi Wing Ng, Geetanjali Deole, Zhuofan Chen, Charles L. Raison

Research output: Contribution to journalReview articlepeer-review

9 Scopus citations

Abstract

Background Scientific interest in the therapeutic effects of classical psychedelics has increased in the past two decades. The psychological effects of these substances outside the period of acute intoxication have not been fully characterized. This study aimed to: (1) quantify the effects of psilocybin, ayahuasca, and lysergic acid diethylamide (LSD) on psychological outcomes in the post-acute period; (2) test moderators of these effects; and (3) evaluate adverse effects and risk of bias. Methods We conducted a systematic review and meta-analysis of experimental studies (single-group pre-post or randomized controlled trials) that involved administration of psilocybin, ayahuasca, or LSD to clinical or non-clinical samples and assessed psychological outcomes â

Original languageEnglish (US)
JournalPsychological Medicine
DOIs
StateAccepted/In press - 2020

Keywords

  • Anxiety
  • ayahuasca
  • depression
  • LSD
  • meta-analysis
  • psilocybin
  • psychedelics
  • psychological effects

ASJC Scopus subject areas

  • Applied Psychology
  • Psychiatry and Mental health

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