Positive and negative roles of CD72 in B cell function

Hsin Jung Wu; Subbarao Bondada

doi:10.1385/IR:25:2:155

Positive and negative roles of CD72 in B cell function

Hsin Jung Wu, Subbarao Bondada

Research output: Contribution to journal › Article › peer-review

17 Scopus citations

Abstract

Regulation of B cell activation depends on integration of signals transmitted by the B cell receptor (BCR) and a variety of co-receptors. CD72 is a B cell co-receptor that is expressed in all stages of B cell development except plasma cells. Ligation of CD72 enhances B cell growth and differentiation. Recently, the class IV semaphoring, CD100, has been identified as the natural ligand for CD72. Cytoplasmic domain of CD72 has been shown to be associated with SHP-1 leading to the proposal that the positive effects of CD72 on B cell response may result from sequestration of negative signals from BCR. However, association of CD72 with Grb2 and/or CD19 suggests that CD72 could transmit positive signals. Based on these data, we propose a dual signaling model of CD72.

Original language	English (US)
Pages (from-to)	155-166
Number of pages	12
Journal	Immunologic Research
Volume	25
Issue number	2
DOIs	https://doi.org/10.1385/IR:25:2:155
State	Published - 2002

Keywords

Cell surface molecules
Cellular proliferation
Co-receptor
Co-stimulatory molecules
Signal transduction

ASJC Scopus subject areas

Immunology

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10.1385/IR:25:2:155

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title = "Positive and negative roles of CD72 in B cell function",

abstract = "Regulation of B cell activation depends on integration of signals transmitted by the B cell receptor (BCR) and a variety of co-receptors. CD72 is a B cell co-receptor that is expressed in all stages of B cell development except plasma cells. Ligation of CD72 enhances B cell growth and differentiation. Recently, the class IV semaphoring, CD100, has been identified as the natural ligand for CD72. Cytoplasmic domain of CD72 has been shown to be associated with SHP-1 leading to the proposal that the positive effects of CD72 on B cell response may result from sequestration of negative signals from BCR. However, association of CD72 with Grb2 and/or CD19 suggests that CD72 could transmit positive signals. Based on these data, we propose a dual signaling model of CD72.",

keywords = "Cell surface molecules, Cellular proliferation, Co-receptor, Co-stimulatory molecules, Signal transduction",

author = "Wu, {Hsin Jung} and Subbarao Bondada",

note = "Funding Information: Our thanks are due to Dr. Ralph L. Chelvarajan for a critical review of the manuscript and to Drs. N. Muthusamy and C. Venkataraman for their early contributions to defining the CD72 signaling pathway. This work was supported by Grants AI 21490 and AG 05731 to S.B. from the National Institutes of Health.",

year = "2002",

doi = "10.1385/IR:25:2:155",

language = "English (US)",

volume = "25",

pages = "155--166",

journal = "Immunologic Research",

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publisher = "Humana Press",

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T1 - Positive and negative roles of CD72 in B cell function

AU - Wu, Hsin Jung

AU - Bondada, Subbarao

N1 - Funding Information: Our thanks are due to Dr. Ralph L. Chelvarajan for a critical review of the manuscript and to Drs. N. Muthusamy and C. Venkataraman for their early contributions to defining the CD72 signaling pathway. This work was supported by Grants AI 21490 and AG 05731 to S.B. from the National Institutes of Health.

PY - 2002

Y1 - 2002

N2 - Regulation of B cell activation depends on integration of signals transmitted by the B cell receptor (BCR) and a variety of co-receptors. CD72 is a B cell co-receptor that is expressed in all stages of B cell development except plasma cells. Ligation of CD72 enhances B cell growth and differentiation. Recently, the class IV semaphoring, CD100, has been identified as the natural ligand for CD72. Cytoplasmic domain of CD72 has been shown to be associated with SHP-1 leading to the proposal that the positive effects of CD72 on B cell response may result from sequestration of negative signals from BCR. However, association of CD72 with Grb2 and/or CD19 suggests that CD72 could transmit positive signals. Based on these data, we propose a dual signaling model of CD72.

AB - Regulation of B cell activation depends on integration of signals transmitted by the B cell receptor (BCR) and a variety of co-receptors. CD72 is a B cell co-receptor that is expressed in all stages of B cell development except plasma cells. Ligation of CD72 enhances B cell growth and differentiation. Recently, the class IV semaphoring, CD100, has been identified as the natural ligand for CD72. Cytoplasmic domain of CD72 has been shown to be associated with SHP-1 leading to the proposal that the positive effects of CD72 on B cell response may result from sequestration of negative signals from BCR. However, association of CD72 with Grb2 and/or CD19 suggests that CD72 could transmit positive signals. Based on these data, we propose a dual signaling model of CD72.

KW - Cell surface molecules

KW - Cellular proliferation

KW - Co-receptor

KW - Co-stimulatory molecules

KW - Signal transduction

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DO - 10.1385/IR:25:2:155

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SN - 0257-277X

VL - 25

SP - 155

EP - 166

JO - Immunologic Research

JF - Immunologic Research

IS - 2

ER -

Positive and negative roles of CD72 in B cell function

Abstract

Keywords

ASJC Scopus subject areas

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