Portal and systemic bacteraemia and endotoxaemia in liver disease

D. R. Triger, T. D. Boyer, J. Levin

Research output: Contribution to journalArticlepeer-review

107 Scopus citations


Using a percutaneous transhepatic technique, blood was obtained from the portal veins of 30 patients with various hepatic disorders and examined for the presence of bacteria and endotoxin. Simultaneous samples also were drawn from hepatic and peripheral veins. In three cases, portal vein cultures grew diphtheroids, which were of doubtful significance, while all hepatic and peripheral cultures were sterile. Endotoxin was detected in seven portal vein samples; in none of these patients were the hepatic or peripheral blood samples positive. In three cases, only peripheral blood samples were positive for endotoxin. It was concluded that portal bacteraemia occurs as infrequently in patients with liver disease as in those without. Portal endotoxaemia was detected in patients with all degrees of liver disease but, even in patients with moderately severe portal hypertension, the liver may remain an effective filter of endotoxin.

Original languageEnglish (US)
Pages (from-to)935-939
Number of pages5
Issue number10
StatePublished - 1978
Externally publishedYes

ASJC Scopus subject areas

  • Gastroenterology


Dive into the research topics of 'Portal and systemic bacteraemia and endotoxaemia in liver disease'. Together they form a unique fingerprint.

Cite this