TY - JOUR
T1 - Porcine KLF gene family
T2 - Structure, mapping, and phylogenetic analysis
AU - Chen, Zhilong
AU - Lei, Ting
AU - Chen, Xiaodong
AU - Zhang, Jian
AU - Yu, An
AU - Long, Qinqiang
AU - Long, Huan
AU - Jin, Dan
AU - Gan, Li
AU - Yang, Zaiqing
N1 - Funding Information:
We are grateful to Dr. Martine Yerle and Denis Milan (INRA, Castanet-Tolosan, France) for kindly providing the RH panel. This work was supported by the grants from Major Projects of National Science and Technology ( 2009ZX08009-151B ), 973 Programme ( 2006CB102100 ), 863 Programme ( 2008AA10Z134 , 2006AA10Z140 ), High Education Doctorial Subject Research Programme ( 20060504016 ), General Programme ( 30771585 ) and Key Programe of National Natural Science Foundation of China.
PY - 2010/2
Y1 - 2010/2
N2 - The Kruppel-like factors (KLFs) belong to the family of zinc finger-containing transcription factors that regulates a diverse array of cellular processes, including cell proliferation, differentiation, and apoptosis. Here we reported the structure, mapping and phylogenetic analysis of KLF gene family in pigs. Comparative analyses revealed strong conservation between pig and human KLFs at the genomic and protein structure levels. Porcine KLF 1-17 were dispersedly located on chromosomes 1, 2, 3, 4, 6, 7, 8, 10, 11, 15, 18 and X, respectively. Based on the phylogenetic analysis, we proposed that KLFs have undergone extensive expansion over the course of evolution. Finally, we identified a characteristic motif in KLF zinc finger domains that can be used to accurately predict potential KLF proteins. The current work represents the first comprehensive study of KLF genes in pigs and provides a foundation for future studies concerning structural, functional, and evolutionary analyses of KLF gene family.
AB - The Kruppel-like factors (KLFs) belong to the family of zinc finger-containing transcription factors that regulates a diverse array of cellular processes, including cell proliferation, differentiation, and apoptosis. Here we reported the structure, mapping and phylogenetic analysis of KLF gene family in pigs. Comparative analyses revealed strong conservation between pig and human KLFs at the genomic and protein structure levels. Porcine KLF 1-17 were dispersedly located on chromosomes 1, 2, 3, 4, 6, 7, 8, 10, 11, 15, 18 and X, respectively. Based on the phylogenetic analysis, we proposed that KLFs have undergone extensive expansion over the course of evolution. Finally, we identified a characteristic motif in KLF zinc finger domains that can be used to accurately predict potential KLF proteins. The current work represents the first comprehensive study of KLF genes in pigs and provides a foundation for future studies concerning structural, functional, and evolutionary analyses of KLF gene family.
KW - Chromosome mapping
KW - Clone
KW - KLFs
KW - Phylogenetic analysis
KW - Pig
KW - Structure
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U2 - 10.1016/j.ygeno.2009.11.001
DO - 10.1016/j.ygeno.2009.11.001
M3 - Article
C2 - 19941950
AN - SCOPUS:75749129805
VL - 95
SP - 111
EP - 119
JO - Genomics
JF - Genomics
SN - 0888-7543
IS - 2
ER -