Poor rectal absorption of trimethoprim/sulphamethoxazole in treating Pneumocystis carinii pneumonia

Robert T. Dorr; J. Robert Powell; Meredith Heick; David W. Barry

doi:10.1136/pgmj.57.664.123

Poor rectal absorption of trimethoprim/sulphamethoxazole in treating Pneumocystis carinii pneumonia

Robert T. Dorr, J. Robert Powell, Meredith Heick, David W. Barry

Cancer Center

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Abstract

A 24-year-old female with Hodgkin's disease and Pneumocystis carinii pneumonia was treated with trimethoprim/ sulphamethoxazole (TMP/SMX) tablets. Because treatment failure was feared owing to chronic emesis potentially resulting in incomplete drug absorption, the same TMP/SMX dose was administered by rectal suppositories after the 5th day of oral dosing. The relative fractions (rectal/oral) of the suppository dose absorbed for TMP and SMX were 3 0% and 19.5% respectively. When TMP/SMX treatment is required and the oral route is not practical, the investigational i.v. preparation should be obtained.

Original language	English (US)
Pages (from-to)	123-125
Number of pages	3
Journal	Postgraduate Medical Journal
Volume	57
Issue number	664
DOIs	https://doi.org/10.1136/pgmj.57.664.123
State	Published - 1981

ASJC Scopus subject areas

General Medicine

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abstract = "A 24-year-old female with Hodgkin's disease and Pneumocystis carinii pneumonia was treated with trimethoprim/ sulphamethoxazole (TMP/SMX) tablets. Because treatment failure was feared owing to chronic emesis potentially resulting in incomplete drug absorption, the same TMP/SMX dose was administered by rectal suppositories after the 5th day of oral dosing. The relative fractions (rectal/oral) of the suppository dose absorbed for TMP and SMX were 3 0% and 19.5% respectively. When TMP/SMX treatment is required and the oral route is not practical, the investigational i.v. preparation should be obtained.",

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AU - Barry, David W.

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AB - A 24-year-old female with Hodgkin's disease and Pneumocystis carinii pneumonia was treated with trimethoprim/ sulphamethoxazole (TMP/SMX) tablets. Because treatment failure was feared owing to chronic emesis potentially resulting in incomplete drug absorption, the same TMP/SMX dose was administered by rectal suppositories after the 5th day of oral dosing. The relative fractions (rectal/oral) of the suppository dose absorbed for TMP and SMX were 3 0% and 19.5% respectively. When TMP/SMX treatment is required and the oral route is not practical, the investigational i.v. preparation should be obtained.

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Poor rectal absorption of trimethoprim/sulphamethoxazole in treating Pneumocystis carinii pneumonia

Abstract

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