Ponicidin and Oridonin Are Responsible for the Antiangiogenic Activity of Rabdosia rubescens, a Constituent of the Herbal Supplement PC SPES

Linda C. Meade-Tollin; E. M.Kithsiri Wijeratne; Deborah Cooper; Mischa Guild; Edlyn Jon; Anne Fritz; Guang Xiong Zhou; Luke Whitesell; Jing Yu Liang; A. A.Leslie Gunatilaka

doi:10.1021/np0304114

Ponicidin and Oridonin Are Responsible for the Antiangiogenic Activity of Rabdosia rubescens, a Constituent of the Herbal Supplement PC SPES

Linda C. Meade-Tollin, E. M.Kithsiri Wijeratne, Deborah Cooper, Mischa Guild, Edlyn Jon, Anne Fritz, Guang Xiong Zhou, Luke Whitesell, Jing Yu Liang, A. A.Leslie Gunatilaka

Research output: Contribution to journal › Article › peer-review

74 Scopus citations

Abstract

Antiangiogenic activity has been identified in an aqueous EtOH extract of Rabdosia rubescens, a component of the dietary supplement PC SPES. Bioassay-guided fractionation using a novel in vitro human endothelial cell-based assay for angiogenesis afforded the diterpenoids ponicidin (1) and oridonin (2), with significant antiangiogenic activity at subcytotoxic concentrations, suggesting that these constituents may strongly contribute to the demonstrated clinical efficacy of PC SPES as a treatment for advanced prostate cancer.

Original language	English (US)
Pages (from-to)	2-4
Number of pages	3
Journal	Journal Of Natural Products
Volume	67
Issue number	1
DOIs	https://doi.org/10.1021/np0304114
State	Published - Jan 2004

ASJC Scopus subject areas

Analytical Chemistry
Molecular Medicine
Pharmacology
Pharmaceutical Science
Drug Discovery
Complementary and alternative medicine
Organic Chemistry

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Meade-Tollin, L. C., Wijeratne, E. M. K., Cooper, D., Guild, M., Jon, E., Fritz, A., Zhou, G. X., Whitesell, L., Liang, J. Y., & Gunatilaka, A. A. L. (2004). Ponicidin and Oridonin Are Responsible for the Antiangiogenic Activity of Rabdosia rubescens, a Constituent of the Herbal Supplement PC SPES. Journal Of Natural Products, 67(1), 2-4. https://doi.org/10.1021/np0304114

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abstract = "Antiangiogenic activity has been identified in an aqueous EtOH extract of Rabdosia rubescens, a component of the dietary supplement PC SPES. Bioassay-guided fractionation using a novel in vitro human endothelial cell-based assay for angiogenesis afforded the diterpenoids ponicidin (1) and oridonin (2), with significant antiangiogenic activity at subcytotoxic concentrations, suggesting that these constituents may strongly contribute to the demonstrated clinical efficacy of PC SPES as a treatment for advanced prostate cancer.",

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year = "2004",

month = jan,

doi = "10.1021/np0304114",

language = "English (US)",

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AU - Wijeratne, E. M.Kithsiri

AU - Cooper, Deborah

AU - Guild, Mischa

AU - Jon, Edlyn

AU - Fritz, Anne

AU - Zhou, Guang Xiong

AU - Whitesell, Luke

AU - Liang, Jing Yu

AU - Gunatilaka, A. A.Leslie

PY - 2004/1

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AB - Antiangiogenic activity has been identified in an aqueous EtOH extract of Rabdosia rubescens, a component of the dietary supplement PC SPES. Bioassay-guided fractionation using a novel in vitro human endothelial cell-based assay for angiogenesis afforded the diterpenoids ponicidin (1) and oridonin (2), with significant antiangiogenic activity at subcytotoxic concentrations, suggesting that these constituents may strongly contribute to the demonstrated clinical efficacy of PC SPES as a treatment for advanced prostate cancer.

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Ponicidin and Oridonin Are Responsible for the Antiangiogenic Activity of Rabdosia rubescens, a Constituent of the Herbal Supplement PC SPES

Abstract

ASJC Scopus subject areas

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