Polymorphisms of the ADAM33 gene are associated with accelerated lung function decline in asthma

H. Jongepier, H. M. Boezen, A. Dijkstra, T. D. Howard, J. M. Vonk, G. H. Koppelman, S. L. Zheng, D. A. Meyers, E. R. Bleecker, D. S. Postma

Research output: Contribution to journalArticlepeer-review

190 Scopus citations

Abstract

Background: Asthma is a genetically complex disease characterized by respiratory symptoms, intermittent airway obstruction and airway hyper-responsiveness due to airway inflammation and remodelling. The ADAM33 gene is associated with asthma and airway hyper-responsiveness and is postulated as a gene for airway remodelling. Objective: To investigate whether polymorphisms of the ADAM33 gene are associated with accelerated lung function decline in patients with asthma. Methods: In a cohort of 200 asthma patients followed over 20 years, eight single nucleotide polymorphisms of the ADAM33 gene were analysed to estimate their effect on annual FEV1 decline. Results: The rare allele of the S_2 polymorphism was significantly associated with excess decline in FEV1 (P < 0.05). Conclusion: These findings suggest that a variant in ADAM33 is not only important in the development of asthma but also in disease progression, possibly related to enhanced airway remodelling.

Original languageEnglish (US)
Pages (from-to)757-760
Number of pages4
JournalClinical and Experimental Allergy
Volume34
Issue number5
DOIs
StatePublished - May 2004
Externally publishedYes

Keywords

  • Bronchial asthma
  • Disease progression
  • FEV
  • Longitudinal studies
  • SNP

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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