Abstract
Background: Asthma is a genetically complex disease characterized by respiratory symptoms, intermittent airway obstruction and airway hyper-responsiveness due to airway inflammation and remodelling. The ADAM33 gene is associated with asthma and airway hyper-responsiveness and is postulated as a gene for airway remodelling. Objective: To investigate whether polymorphisms of the ADAM33 gene are associated with accelerated lung function decline in patients with asthma. Methods: In a cohort of 200 asthma patients followed over 20 years, eight single nucleotide polymorphisms of the ADAM33 gene were analysed to estimate their effect on annual FEV1 decline. Results: The rare allele of the S_2 polymorphism was significantly associated with excess decline in FEV1 (P < 0.05). Conclusion: These findings suggest that a variant in ADAM33 is not only important in the development of asthma but also in disease progression, possibly related to enhanced airway remodelling.
Original language | English (US) |
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Pages (from-to) | 757-760 |
Number of pages | 4 |
Journal | Clinical and Experimental Allergy |
Volume | 34 |
Issue number | 5 |
DOIs | |
State | Published - May 2004 |
Externally published | Yes |
Keywords
- Bronchial asthma
- Disease progression
- FEV
- Longitudinal studies
- SNP
ASJC Scopus subject areas
- Immunology and Allergy
- Immunology