Polymorphisms in the CYP1B1 gene are associated with increased risk of prostate cancer

B. L. Chang, S. L. Zheng, S. D. Isaacs, A. R. Turner, G. A. Hawkins, K. E. Wiley, E. R. Bleecker, P. C. Walsh, D. A. Meyers, W. B. Isaacs, J. Xu

Research output: Contribution to journalArticlepeer-review

58 Scopus citations


CYP1B1 has been evaluated as a candidate gene for various cancers because of its function in activating environmental procarcinogens and catalysing the conversion of oestrogens to genotoxic catechol oestrogens. To test the hypothesis that genetic polymorphisms in the CYP1B1 gene may associate with the risk for prostate cancer (CaP), we compared the allele, genotype, and haplotype frequencies of 13 single nucleotide polymorphisms (SNPs) of CYP1B1 among 159 hereditary prostate cancer (HPC) probands, 245 sporadic CaP cases, and 222 unaffected men. When each of the SNPs was analysed separately, marginally significant differences were observed for allele frequencies between sporadic cases and controls for three consecutive SNPs (-1001C/T, -263G/A, and -13C/T, P=0.04-0.07). Similarly, marginally significant differences between sporadic cases and controls in the frequency of variant allele carriers were observed for five consecutive SNPs (-1001C/T, -263G/A, -13C/T, +142C/G, and +355G/T, P=0.02-0.08). Interestingly, when the combination of these five SNPs was analysed using a haplotype approach, a larger difference was found (P=0.009). One frequent haplotype (C-G-C-C-G of -1001C/T, -263G/A, -13C/T, +142C/G, and +355G/T) was associated with an increased risk for CaP, while the other frequent haplotype (T-A-T-G-T) was associated with a decreased risk for CaP. These findings suggest that genetic polymorphisms in CYP1B1 may modify the risk for CaP.

Original languageEnglish (US)
Pages (from-to)1524-1529
Number of pages6
JournalBritish journal of cancer
Issue number8
StatePublished - Oct 20 2003
Externally publishedYes


  • Association
  • CYP1B1
  • Haplotype
  • Hereditary
  • Prostate cancer

ASJC Scopus subject areas

  • Oncology
  • Cancer Research


Dive into the research topics of 'Polymorphisms in the CYP1B1 gene are associated with increased risk of prostate cancer'. Together they form a unique fingerprint.

Cite this