Polymorphisms in SLC6A4, PAH, GABRB3, and MAOB and modification of psychotic disorder features

Sarah E. Bergen; Ayman H. Fanous; Dermot Walsh; F. Anthony O'Neill; Kenneth S. Kendler

doi:10.1016/j.schres.2009.02.009

Polymorphisms in SLC6A4, PAH, GABRB3, and MAOB and modification of psychotic disorder features

Sarah E. Bergen, Ayman H. Fanous, Dermot Walsh, F. Anthony O'Neill, Kenneth S. Kendler

Research output: Contribution to journal › Article › peer-review

33 Scopus citations

Abstract

We tested four genes [phenylalanine hydroxylase (PAH), the serotonin transporter (SLC6A4), monoamine oxidase B (MAOB), and the gamma-aminobutyric acid A receptor β-3 subunit (GABRB3)] for their impact on five schizophrenia symptom factors: delusions, hallucinations, mania, depression, and negative symptoms. In a 90 family subset of the Irish Study of High Density Schizophrenia Families, the PAH 232 bp microsatellite allele demonstrated significant association with the delusions factor using both QTDT (F = 8.0, p = .031) and QPDTPHASE (chi-square = 12.54, p = .028). Also, a significant association between the GABRB3 191 bp allele and the hallucinations factor was detected using QPDTPHASE (chi-square = 15.51, p = .030), but not QTDT (chi-square = 2.07, p = .560).

Original language	English (US)
Pages (from-to)	94-97
Number of pages	4
Journal	Schizophrenia Research
Volume	109
Issue number	1-3
DOIs	https://doi.org/10.1016/j.schres.2009.02.009
State	Published - Apr 2009
Externally published	Yes

Keywords

GABRB3
MAOB
PAH
SERT
SLC6A4
association
modifier
schizophrenia

ASJC Scopus subject areas

Psychiatry and Mental health
Biological Psychiatry

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10.1016/j.schres.2009.02.009

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title = "Polymorphisms in SLC6A4, PAH, GABRB3, and MAOB and modification of psychotic disorder features",

abstract = "We tested four genes [phenylalanine hydroxylase (PAH), the serotonin transporter (SLC6A4), monoamine oxidase B (MAOB), and the gamma-aminobutyric acid A receptor β-3 subunit (GABRB3)] for their impact on five schizophrenia symptom factors: delusions, hallucinations, mania, depression, and negative symptoms. In a 90 family subset of the Irish Study of High Density Schizophrenia Families, the PAH 232 bp microsatellite allele demonstrated significant association with the delusions factor using both QTDT (F = 8.0, p = .031) and QPDTPHASE (chi-square = 12.54, p = .028). Also, a significant association between the GABRB3 191 bp allele and the hallucinations factor was detected using QPDTPHASE (chi-square = 15.51, p = .030), but not QTDT (chi-square = 2.07, p = .560).",

keywords = "GABRB3, MAOB, PAH, SERT, SLC6A4, association, modifier, schizophrenia",

author = "Bergen, {Sarah E.} and Fanous, {Ayman H.} and Dermot Walsh and O'Neill, {F. Anthony} and Kendler, {Kenneth S.}",

note = "Funding Information: This work was supported by NIH grants MH41953 and MH20030. We would also like to thank Bradley Todd Webb, PhD for his assistance with primer information retrieval.",

year = "2009",

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doi = "10.1016/j.schres.2009.02.009",

language = "English (US)",

volume = "109",

pages = "94--97",

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AU - Bergen, Sarah E.

AU - Fanous, Ayman H.

AU - Walsh, Dermot

AU - O'Neill, F. Anthony

AU - Kendler, Kenneth S.

N1 - Funding Information: This work was supported by NIH grants MH41953 and MH20030. We would also like to thank Bradley Todd Webb, PhD for his assistance with primer information retrieval.

PY - 2009/4

Y1 - 2009/4

N2 - We tested four genes [phenylalanine hydroxylase (PAH), the serotonin transporter (SLC6A4), monoamine oxidase B (MAOB), and the gamma-aminobutyric acid A receptor β-3 subunit (GABRB3)] for their impact on five schizophrenia symptom factors: delusions, hallucinations, mania, depression, and negative symptoms. In a 90 family subset of the Irish Study of High Density Schizophrenia Families, the PAH 232 bp microsatellite allele demonstrated significant association with the delusions factor using both QTDT (F = 8.0, p = .031) and QPDTPHASE (chi-square = 12.54, p = .028). Also, a significant association between the GABRB3 191 bp allele and the hallucinations factor was detected using QPDTPHASE (chi-square = 15.51, p = .030), but not QTDT (chi-square = 2.07, p = .560).

AB - We tested four genes [phenylalanine hydroxylase (PAH), the serotonin transporter (SLC6A4), monoamine oxidase B (MAOB), and the gamma-aminobutyric acid A receptor β-3 subunit (GABRB3)] for their impact on five schizophrenia symptom factors: delusions, hallucinations, mania, depression, and negative symptoms. In a 90 family subset of the Irish Study of High Density Schizophrenia Families, the PAH 232 bp microsatellite allele demonstrated significant association with the delusions factor using both QTDT (F = 8.0, p = .031) and QPDTPHASE (chi-square = 12.54, p = .028). Also, a significant association between the GABRB3 191 bp allele and the hallucinations factor was detected using QPDTPHASE (chi-square = 15.51, p = .030), but not QTDT (chi-square = 2.07, p = .560).

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KW - modifier

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Polymorphisms in SLC6A4, PAH, GABRB3, and MAOB and modification of psychotic disorder features

Abstract

Keywords

ASJC Scopus subject areas

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