Polymorphism of human telomeric quadruplex structures

Jixun Dai; Megan Carver; Danzhou Yang

doi:10.1016/j.biochi.2008.02.026

Polymorphism of human telomeric quadruplex structures

Jixun Dai, Megan Carver, Danzhou Yang

Pharmacology and Toxicology

Research output: Contribution to journal › Review article › peer-review

352 Scopus citations

Abstract

Human telomeric DNA consists of tandem repeats of the sequence d(TTAGGG). Compounds that can stabilize the intramolecular DNA G-quadruplexes formed in the human telomeric sequence have been shown to inhibit the activity of telomerase and telomere maintenance, thus the telomeric DNA G-quadruplex has been considered as an attractive target for cancer therapeutic intervention. Knowledge of intramolecular human telomeric G-quadruplex structure(s) formed under physiological conditions is important for structure-based rational drug design and thus has been the subject of intense investigation. This review will give an overview of recent progress on the intramolecular human telomeric G-quadruplex structures formed in K⁺ solution. It will also give insight into the structure polymorphism of human telomeric sequences and its implications for drug targeting.

Original language	English (US)
Pages (from-to)	1172-1183
Number of pages	12
Journal	Biochimie
Volume	90
Issue number	8
DOIs	https://doi.org/10.1016/j.biochi.2008.02.026
State	Published - Aug 2008

Keywords

Anticancer drug target
G-quadruplex
Human telomere
NMR
Potassium structure
Structure polymorphism

ASJC Scopus subject areas

Biochemistry

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10.1016/j.biochi.2008.02.026

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title = "Polymorphism of human telomeric quadruplex structures",

abstract = "Human telomeric DNA consists of tandem repeats of the sequence d(TTAGGG). Compounds that can stabilize the intramolecular DNA G-quadruplexes formed in the human telomeric sequence have been shown to inhibit the activity of telomerase and telomere maintenance, thus the telomeric DNA G-quadruplex has been considered as an attractive target for cancer therapeutic intervention. Knowledge of intramolecular human telomeric G-quadruplex structure(s) formed under physiological conditions is important for structure-based rational drug design and thus has been the subject of intense investigation. This review will give an overview of recent progress on the intramolecular human telomeric G-quadruplex structures formed in K+ solution. It will also give insight into the structure polymorphism of human telomeric sequences and its implications for drug targeting.",

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T1 - Polymorphism of human telomeric quadruplex structures

AU - Dai, Jixun

AU - Carver, Megan

AU - Yang, Danzhou

PY - 2008/8

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N2 - Human telomeric DNA consists of tandem repeats of the sequence d(TTAGGG). Compounds that can stabilize the intramolecular DNA G-quadruplexes formed in the human telomeric sequence have been shown to inhibit the activity of telomerase and telomere maintenance, thus the telomeric DNA G-quadruplex has been considered as an attractive target for cancer therapeutic intervention. Knowledge of intramolecular human telomeric G-quadruplex structure(s) formed under physiological conditions is important for structure-based rational drug design and thus has been the subject of intense investigation. This review will give an overview of recent progress on the intramolecular human telomeric G-quadruplex structures formed in K+ solution. It will also give insight into the structure polymorphism of human telomeric sequences and its implications for drug targeting.

AB - Human telomeric DNA consists of tandem repeats of the sequence d(TTAGGG). Compounds that can stabilize the intramolecular DNA G-quadruplexes formed in the human telomeric sequence have been shown to inhibit the activity of telomerase and telomere maintenance, thus the telomeric DNA G-quadruplex has been considered as an attractive target for cancer therapeutic intervention. Knowledge of intramolecular human telomeric G-quadruplex structure(s) formed under physiological conditions is important for structure-based rational drug design and thus has been the subject of intense investigation. This review will give an overview of recent progress on the intramolecular human telomeric G-quadruplex structures formed in K+ solution. It will also give insight into the structure polymorphism of human telomeric sequences and its implications for drug targeting.

KW - Anticancer drug target

KW - G-quadruplex

KW - Human telomere

KW - NMR

KW - Potassium structure

KW - Structure polymorphism

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JO - Biochimie

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Polymorphism of human telomeric quadruplex structures

Abstract

Keywords

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