Polymer-drug conjugates: Manipulation of drug delivery kinetics

Colin G. Pitt, Jason Wertheim, C. T. Wang, Subodh S. Shah

Research output: Contribution to journalArticlepeer-review

1 Scopus citations


Three methods of manipulating the kinetics of hydrolysis of polymer conjugates were evaluated. It was demonstrated that either first-order, zero-order or S-shaped kinetic profiles could be achieved by systematic changes in the chemical composition of several series of model side-chain substituted polyacrylates. The changes in kinetics were shown to arise from an increase in the rate constant during solvolysis, resulting from predictable changes in either the water content, secondary structure, or LCST of the polymer conjugate.

Original languageEnglish (US)
Pages (from-to)225-234
Number of pages10
JournalMacromolecular Symposia
StatePublished - Sep 1997
Externally publishedYes

ASJC Scopus subject areas

  • Condensed Matter Physics
  • Organic Chemistry
  • Polymers and Plastics
  • Materials Chemistry


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