Polyamine–DNA Interactions: Possible Site of New Cancer Chemotherapeutic Intervention

Laurence J. Marton; Burt G. Feuerstein

doi:10.1023/A:1016375705487

Polyamine–DNA Interactions: Possible Site of New Cancer Chemotherapeutic Intervention

Laurence J. Marton, Burt G. Feuerstein

Medicine Administration

Research output: Contribution to journal › Review article › peer-review

32 Scopus citations

Abstract

The effects of polyamines on the structure of nucleic acids in cell-free systems and in cell culture systems are reviewed. Evidence suggests that polyamine depletion inhibits cell growth and may cause conformational changes in DNA. These effects may be exploited to cause changes in the action of drugs and may be used to advantage in combination treatment protocols. A discussion of theoretical models of the interactions, physicochemical evidence for conformational changes, and the effects of anticancer drugs in cells depleted of polyamines is presented.

Original language	English (US)
Pages (from-to)	311-317
Number of pages	7
Journal	Pharmaceutical Research: An Official Journal of the American Association of Pharmaceutical Scientists
Volume	3
Issue number	6
DOIs	https://doi.org/10.1023/A:1016375705487
State	Published - Dec 1986

Keywords

cancer chemotherapy
molecular modeling
nucleic acid conformation
nucleic acids
polyamines

ASJC Scopus subject areas

Biotechnology
Molecular Medicine
Pharmacology
Pharmaceutical Science
Organic Chemistry
Pharmacology (medical)

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title = "Polyamine–DNA Interactions: Possible Site of New Cancer Chemotherapeutic Intervention",

abstract = "The effects of polyamines on the structure of nucleic acids in cell-free systems and in cell culture systems are reviewed. Evidence suggests that polyamine depletion inhibits cell growth and may cause conformational changes in DNA. These effects may be exploited to cause changes in the action of drugs and may be used to advantage in combination treatment protocols. A discussion of theoretical models of the interactions, physicochemical evidence for conformational changes, and the effects of anticancer drugs in cells depleted of polyamines is presented.",

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T1 - Polyamine–DNA Interactions

T2 - Possible Site of New Cancer Chemotherapeutic Intervention

AU - Marton, Laurence J.

AU - Feuerstein, Burt G.

PY - 1986/12

Y1 - 1986/12

N2 - The effects of polyamines on the structure of nucleic acids in cell-free systems and in cell culture systems are reviewed. Evidence suggests that polyamine depletion inhibits cell growth and may cause conformational changes in DNA. These effects may be exploited to cause changes in the action of drugs and may be used to advantage in combination treatment protocols. A discussion of theoretical models of the interactions, physicochemical evidence for conformational changes, and the effects of anticancer drugs in cells depleted of polyamines is presented.

AB - The effects of polyamines on the structure of nucleic acids in cell-free systems and in cell culture systems are reviewed. Evidence suggests that polyamine depletion inhibits cell growth and may cause conformational changes in DNA. These effects may be exploited to cause changes in the action of drugs and may be used to advantage in combination treatment protocols. A discussion of theoretical models of the interactions, physicochemical evidence for conformational changes, and the effects of anticancer drugs in cells depleted of polyamines is presented.

KW - cancer chemotherapy

KW - molecular modeling

KW - nucleic acid conformation

KW - nucleic acids

KW - polyamines

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JO - Pharmaceutical Research: An Official Journal of the American Association of Pharmaceutical Scientists

JF - Pharmaceutical Research: An Official Journal of the American Association of Pharmaceutical Scientists

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Polyamine–DNA Interactions: Possible Site of New Cancer Chemotherapeutic Intervention

Abstract

Keywords

ASJC Scopus subject areas

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