Abstract
Skeletal muscle fibers are specialized at the site of the neuromuscular synapse, and this polarity is acquired during development and maintained in the adult as a consequence of inductive interactions between nerve and muscle. This review summarizes recent experiments which demonstrate that two different signalling pathways, a transcriptional pathway and a post-translational pathway, have an important role in the formation and maintenance of the neuromuscular synapse and mediate the induction of polarity in skeletal muscle fibers.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 59-65 |
| Number of pages | 7 |
| Journal | Seminars in Developmental Biology |
| Volume | 6 |
| Issue number | 1 |
| DOIs | |
| State | Published - Feb 1995 |
Keywords
- acetylcholine receptors
- agrin
- dystroglycan
- erbB
- neuregulin
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