Polarity in skeletal muscle cells is induced by innervation

Steven J. Burden; Sangmee Ahn Jo; Jichen Tang; Xuejun Zhu; James E. Yeadon; Alexander M. Simon

doi:10.1016/S1044-5781(06)80085-X

Polarity in skeletal muscle cells is induced by innervation

Steven J. Burden, Sangmee Ahn Jo, Jichen Tang, Xuejun Zhu, James E. Yeadon, Alexander M. Simon

Physiology

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

Skeletal muscle fibers are specialized at the site of the neuromuscular synapse, and this polarity is acquired during development and maintained in the adult as a consequence of inductive interactions between nerve and muscle. This review summarizes recent experiments which demonstrate that two different signalling pathways, a transcriptional pathway and a post-translational pathway, have an important role in the formation and maintenance of the neuromuscular synapse and mediate the induction of polarity in skeletal muscle fibers.

Original language	English (US)
Pages (from-to)	59-65
Number of pages	7
Journal	Seminars in Developmental Biology
Volume	6
Issue number	1
DOIs	https://doi.org/10.1016/S1044-5781(06)80085-X
State	Published - Feb 1995

Keywords

acetylcholine receptors
agrin
dystroglycan
erbB
neuregulin

Access to Document

10.1016/S1044-5781(06)80085-X

Cite this

@article{3103874fc7d446d2a9ba5d4f0f069227,

title = "Polarity in skeletal muscle cells is induced by innervation",

abstract = "Skeletal muscle fibers are specialized at the site of the neuromuscular synapse, and this polarity is acquired during development and maintained in the adult as a consequence of inductive interactions between nerve and muscle. This review summarizes recent experiments which demonstrate that two different signalling pathways, a transcriptional pathway and a post-translational pathway, have an important role in the formation and maintenance of the neuromuscular synapse and mediate the induction of polarity in skeletal muscle fibers.",

keywords = "acetylcholine receptors, agrin, dystroglycan, erbB, neuregulin",

author = "Burden, {Steven J.} and Jo, {Sangmee Ahn} and Jichen Tang and Xuejun Zhu and Yeadon, {James E.} and Simon, {Alexander M.}",

year = "1995",

month = feb,

doi = "10.1016/S1044-5781(06)80085-X",

language = "English (US)",

volume = "6",

pages = "59--65",

journal = "Seminars in Developmental Biology",

issn = "1044-5781",

publisher = "Saunders",

number = "1",

}

TY - JOUR

T1 - Polarity in skeletal muscle cells is induced by innervation

AU - Burden, Steven J.

AU - Jo, Sangmee Ahn

AU - Tang, Jichen

AU - Zhu, Xuejun

AU - Yeadon, James E.

AU - Simon, Alexander M.

PY - 1995/2

Y1 - 1995/2

N2 - Skeletal muscle fibers are specialized at the site of the neuromuscular synapse, and this polarity is acquired during development and maintained in the adult as a consequence of inductive interactions between nerve and muscle. This review summarizes recent experiments which demonstrate that two different signalling pathways, a transcriptional pathway and a post-translational pathway, have an important role in the formation and maintenance of the neuromuscular synapse and mediate the induction of polarity in skeletal muscle fibers.

AB - Skeletal muscle fibers are specialized at the site of the neuromuscular synapse, and this polarity is acquired during development and maintained in the adult as a consequence of inductive interactions between nerve and muscle. This review summarizes recent experiments which demonstrate that two different signalling pathways, a transcriptional pathway and a post-translational pathway, have an important role in the formation and maintenance of the neuromuscular synapse and mediate the induction of polarity in skeletal muscle fibers.

KW - acetylcholine receptors

KW - agrin

KW - dystroglycan

KW - erbB

KW - neuregulin

UR - http://www.scopus.com/inward/record.url?scp=0343720588&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0343720588&partnerID=8YFLogxK

U2 - 10.1016/S1044-5781(06)80085-X

DO - 10.1016/S1044-5781(06)80085-X

M3 - Article

AN - SCOPUS:0343720588

SN - 1044-5781

VL - 6

SP - 59

EP - 65

JO - Seminars in Developmental Biology

JF - Seminars in Developmental Biology

IS - 1

ER -

Polarity in skeletal muscle cells is induced by innervation

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this