Polarity in skeletal muscle cells is induced by innervation

Steven J. Burden, Sangmee Ahn Jo, Jichen Tang, Xuejun Zhu, James E. Yeadon, Alexander M. Simon

Research output: Contribution to journalArticlepeer-review

5 Scopus citations


Skeletal muscle fibers are specialized at the site of the neuromuscular synapse, and this polarity is acquired during development and maintained in the adult as a consequence of inductive interactions between nerve and muscle. This review summarizes recent experiments which demonstrate that two different signalling pathways, a transcriptional pathway and a post-translational pathway, have an important role in the formation and maintenance of the neuromuscular synapse and mediate the induction of polarity in skeletal muscle fibers.

Original languageEnglish (US)
Pages (from-to)59-65
Number of pages7
JournalSeminars in Developmental Biology
Issue number1
StatePublished - Feb 1995


  • acetylcholine receptors
  • agrin
  • dystroglycan
  • erbB
  • neuregulin


Dive into the research topics of 'Polarity in skeletal muscle cells is induced by innervation'. Together they form a unique fingerprint.

Cite this