TY - JOUR
T1 - Plasticity of Individual Lung Function States from Childhood to Adulthood
AU - Wang, Gang
AU - Hallberg, Jenny
AU - Faner, Rosa
AU - Koefoed, Hans Jacob
AU - Merid, Simon Kebede
AU - Klevebro, Susanna
AU - Bjorkander, Sophia
AU - Gruzieva, Olena
AU - Pershagen, Goran
AU - van Hage, Marianne
AU - Guerra, Stefano
AU - Bottai, Matteo
AU - Georgelis, Antonios
AU - Gehring, Ulrike
AU - Bergstrom, Anna
AU - Vonk, Judith M.
AU - Kull, Inger
AU - Koppelman, Gerard H.
AU - Agusti, Alvar
AU - Melen, Erik
N1 - Funding Information:
Supported by the European Research Council (A TRanslational approach to Identify Biomarkers for Asthma and Lung function impairment), grant agreement 757919; the Swedish Research Council; Forskningsr©adet om Ha€lsa, Arbetsliv och Va€lfa€rd (FORTE) grant 2017-01146; Svenska Forskningsr©adet Formas; Hja€rt-Lungfonden; Strategic Research Area (SFO) Epidemiology; Karolinska Institutet and Region Stockholm ALF project and cohort and database maintenance; Astma-och Allergifo€rbundet Research Foundation and National Institute of Allergy and Infectious Diseases, NIH grant AI135108; Thermo Fisher Scientific (Uppsala, Sweden; reagents for IgE analyses); and Spanish NIH grant ISC-III, Miguel Servet (R.F.). G.W. was supported by the Office of China Postdoctoral Council (No. 56 Document of the office of China postdoctoral council, 2022). PIAMA (Prevention and Incidence of Asthma and Mite Allergy) is supported by the Netherlands Organization for Health Research and Development, the Netherlands Organization for Scientific Research, the Lung Foundation Netherlands (previously Asthma Fund), the Netherlands Ministry of Spatial Planning, Housing, the Environment, the Netherlands Ministry of Health, Welfare, and the National Institute for Public Health and the Environment (RIVM), and Netherlands Lung Foundation grant 4.1.20.003.
Funding Information:
The authors thank all participants, study nurses, data managers, and researchers of the BAMSE cohort. They also thank Kejia Hu, Unit of Integrative Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden, for her critical suggestions on the dependent mixture model and the frame of the manuscript. The authors also thank the CADSET collaboration, funded by the European Respiratory Society (42), which has facilitated interaction and collaboration among investigators and the PIAMA participants and their parents, all researchers, fieldworkers, and data managers for their contributions to the study.
Publisher Copyright:
Copyright © 2023 by the American Thoracic Society.
PY - 2023/2/15
Y1 - 2023/2/15
N2 - Rationale: Recent evidence highlights the importance of optimal lung development during childhood for health throughout life. Objectives: To explore the plasticity of individual lung function states during childhood. Methods: Prebronchodilator FEV1 z-scores determined at age 8, 16, and 24 years in the Swedish population-based birth cohort BAMSE (Swedish abbreviation for Child [Barn], Allergy, Milieu, Stockholm, Epidemiological study) (N = 3,069) were used. An unbiased, data-driven dependent mixture model was applied to explore lung function states and individual state chains. Lung function catch-up was defined as participants moving from low or very low states to normal or high or very high states, and growth failure as moving from normal or high or very high states to low or very low states. At 24 years, we compared respiratory symptoms, small airway function (multiple-breath washout), and circulating inflammatory protein levels, by using proteomics, across states. Models were replicated in the independent Dutch population-based PIAMA (Prevention and Incidence of Asthma and Mite Allergy) cohort. Measurements and Main Results: Five lung function states were identified in BAMSE. Lung function catch-up and growth failure were observed in 74 (14.5%) BAMSE participants with low or very low states and 36 (2.4%) participants with normal or high or very high states, respectively. The occurrence of catch-up and growth failure was replicated in PIAMA. Early-life risk factors were cumulatively associated with the very low state, as well as with catch-up (inverse association) and growth failure. The very low state as well as growth failure were associated with respiratory symptoms, airflow limitation, and small airway dysfunction at adulthood. Proteomics identified IL-6 and CXCL10 (C-X-C motif chemokine 10) as potential biomarkers of impaired lung function development. Conclusions: Individual lung function states during childhood are plastic, including catch-up and growth failure.
AB - Rationale: Recent evidence highlights the importance of optimal lung development during childhood for health throughout life. Objectives: To explore the plasticity of individual lung function states during childhood. Methods: Prebronchodilator FEV1 z-scores determined at age 8, 16, and 24 years in the Swedish population-based birth cohort BAMSE (Swedish abbreviation for Child [Barn], Allergy, Milieu, Stockholm, Epidemiological study) (N = 3,069) were used. An unbiased, data-driven dependent mixture model was applied to explore lung function states and individual state chains. Lung function catch-up was defined as participants moving from low or very low states to normal or high or very high states, and growth failure as moving from normal or high or very high states to low or very low states. At 24 years, we compared respiratory symptoms, small airway function (multiple-breath washout), and circulating inflammatory protein levels, by using proteomics, across states. Models were replicated in the independent Dutch population-based PIAMA (Prevention and Incidence of Asthma and Mite Allergy) cohort. Measurements and Main Results: Five lung function states were identified in BAMSE. Lung function catch-up and growth failure were observed in 74 (14.5%) BAMSE participants with low or very low states and 36 (2.4%) participants with normal or high or very high states, respectively. The occurrence of catch-up and growth failure was replicated in PIAMA. Early-life risk factors were cumulatively associated with the very low state, as well as with catch-up (inverse association) and growth failure. The very low state as well as growth failure were associated with respiratory symptoms, airflow limitation, and small airway dysfunction at adulthood. Proteomics identified IL-6 and CXCL10 (C-X-C motif chemokine 10) as potential biomarkers of impaired lung function development. Conclusions: Individual lung function states during childhood are plastic, including catch-up and growth failure.
KW - asthma
KW - early life risk factors
KW - inflammation
KW - multiple-breath washout
KW - respiratory health
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U2 - 10.1164/rccm.202203-0444OC
DO - 10.1164/rccm.202203-0444OC
M3 - Article
C2 - 36409973
AN - SCOPUS:85148307051
SN - 1073-449X
VL - 207
SP - 406
EP - 415
JO - American Journal of Respiratory and Critical Care Medicine
JF - American Journal of Respiratory and Critical Care Medicine
IS - 4
ER -