Plasminogen kringle 5 induces endothelial cell apoptosis by triggering a voltage-dependent anion channel 1 (VDAC1) positive feedback loop

Lei Li; Ya Chao Yao; Xiao Qiong Gu; Di Che; Cai Qi Ma; Zhi Yu Dai; Cen Li; Ti Zhou; Wei Bin Cai; Zhong Han Yang; Xia Yang; Guo Quan Gao

doi:10.1074/jbc.M114.567792

Plasminogen kringle 5 induces endothelial cell apoptosis by triggering a voltage-dependent anion channel 1 (VDAC1) positive feedback loop

Lei Li
, Ya Chao Yao
, Xiao Qiong Gu
, Di Che
, Cai Qi Ma
, Zhi Yu Dai
, Cen Li
, Ti Zhou
, Wei Bin Cai
, Zhong Han Yang
, Xia Yang
, Guo Quan Gao

Research output: Contribution to journal › Article › peer-review

41 Scopus citations

Abstract

Results: K5 up-regulates VDAC1 through a AKT-GSK3 pathway.

Background: The voltage-dependent anion channel 1 (VDAC1) is identified as a receptor of human plasminogen kringle 5 (K5), but the role and mechanisms of VDAC1 in K5-induced endothelial cell (EC) apoptosis remain elusive.

Conclusion: A positive feedback loop of "VDAC1-AKT-GSK3 VDAC1" mediates K5-induced EC apoptosis.

Significance: This finding provides new perspectives on the mechanisms of K5-induced apoptosis.

Original language	English (US)
Pages (from-to)	32628-32638
Number of pages	11
Journal	Journal of Biological Chemistry
Volume	289
Issue number	47
DOIs	https://doi.org/10.1074/jbc.M114.567792
State	Published - Nov 21 2014
Externally published	Yes

ASJC Scopus subject areas

Biochemistry
Molecular Biology
Cell Biology

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10.1074/jbc.M114.567792

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Li, L., Yao, Y. C., Gu, X. Q., Che, D., Ma, C. Q., Dai, Z. Y., Li, C., Zhou, T., Cai, W. B., Yang, Z. H., Yang, X., & Gao, G. Q. (2014). Plasminogen kringle 5 induces endothelial cell apoptosis by triggering a voltage-dependent anion channel 1 (VDAC1) positive feedback loop. Journal of Biological Chemistry, 289(47), 32628-32638. https://doi.org/10.1074/jbc.M114.567792

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abstract = "Results: K5 up-regulates VDAC1 through a AKT-GSK3 pathway.Background: The voltage-dependent anion channel 1 (VDAC1) is identified as a receptor of human plasminogen kringle 5 (K5), but the role and mechanisms of VDAC1 in K5-induced endothelial cell (EC) apoptosis remain elusive.Conclusion: A positive feedback loop of {"}VDAC1-AKT-GSK3 VDAC1{"} mediates K5-induced EC apoptosis.Significance: This finding provides new perspectives on the mechanisms of K5-induced apoptosis.",

author = "Lei Li and Yao, \{Ya Chao\} and Gu, \{Xiao Qiong\} and Di Che and Ma, \{Cai Qi\} and Dai, \{Zhi Yu\} and Cen Li and Ti Zhou and Cai, \{Wei Bin\} and Yang, \{Zhong Han\} and Xia Yang and Gao, \{Guo Quan\}",

year = "2014",

month = nov,

day = "21",

doi = "10.1074/jbc.M114.567792",

language = "English (US)",

volume = "289",

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AU - Li, Lei

AU - Yao, Ya Chao

AU - Gu, Xiao Qiong

AU - Che, Di

AU - Ma, Cai Qi

AU - Dai, Zhi Yu

AU - Li, Cen

AU - Zhou, Ti

AU - Cai, Wei Bin

AU - Yang, Zhong Han

AU - Yang, Xia

AU - Gao, Guo Quan

PY - 2014/11/21

Y1 - 2014/11/21

N2 - Results: K5 up-regulates VDAC1 through a AKT-GSK3 pathway.Background: The voltage-dependent anion channel 1 (VDAC1) is identified as a receptor of human plasminogen kringle 5 (K5), but the role and mechanisms of VDAC1 in K5-induced endothelial cell (EC) apoptosis remain elusive.Conclusion: A positive feedback loop of "VDAC1-AKT-GSK3 VDAC1" mediates K5-induced EC apoptosis.Significance: This finding provides new perspectives on the mechanisms of K5-induced apoptosis.

AB - Results: K5 up-regulates VDAC1 through a AKT-GSK3 pathway.Background: The voltage-dependent anion channel 1 (VDAC1) is identified as a receptor of human plasminogen kringle 5 (K5), but the role and mechanisms of VDAC1 in K5-induced endothelial cell (EC) apoptosis remain elusive.Conclusion: A positive feedback loop of "VDAC1-AKT-GSK3 VDAC1" mediates K5-induced EC apoptosis.Significance: This finding provides new perspectives on the mechanisms of K5-induced apoptosis.

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DO - 10.1074/jbc.M114.567792

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AN - SCOPUS:84911919847

SN - 0021-9258

VL - 289

SP - 32628

EP - 32638

JO - Journal of Biological Chemistry

JF - Journal of Biological Chemistry

IS - 47

ER -

Plasminogen kringle 5 induces endothelial cell apoptosis by triggering a voltage-dependent anion channel 1 (VDAC1) positive feedback loop

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