Plasminogen kringle 5 induces endothelial cell apoptosis by triggering a voltage-dependent anion channel 1 (VDAC1) positive feedback loop

Lei Li, Ya Chao Yao, Xiao Qiong Gu, Di Che, Cai Qi Ma, Zhi Yu Dai, Cen Li, Ti Zhou, Wei Bin Cai, Zhong Han Yang, Xia Yang, Guo Quan Gao

Research output: Contribution to journalArticlepeer-review

28 Scopus citations

Abstract

Results: K5 up-regulates VDAC1 through a AKT-GSK3 pathway.

Background: The voltage-dependent anion channel 1 (VDAC1) is identified as a receptor of human plasminogen kringle 5 (K5), but the role and mechanisms of VDAC1 in K5-induced endothelial cell (EC) apoptosis remain elusive.

Conclusion: A positive feedback loop of "VDAC1-AKT-GSK3 VDAC1" mediates K5-induced EC apoptosis.

Significance: This finding provides new perspectives on the mechanisms of K5-induced apoptosis.

Original languageEnglish (US)
Pages (from-to)32628-32638
Number of pages11
JournalJournal of Biological Chemistry
Volume289
Issue number47
DOIs
StatePublished - Nov 21 2014
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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