Plasmapheresis and intravenous immune globulin for the treatment of D alloimmunization in pregnancy

Deborah J. Novak, Lisa N. Tyler, Ramakrishna L. Reddy, Michael J. Barsoom

Research output: Contribution to journalArticlepeer-review

15 Scopus citations


The alloimmunized pregnancy can result in fetal and newborn mortality due to fetal anemia. Control of fetal anemia has not been possible until recently, and management consists of following the degree of fetal anemia during gestation until intrauterine transfusion is feasible to support the fetus until delivery. Cordocentesis and intrauterine transfusion have potential complications that have been well documented. Control of fetal anemia via immune modulation utilizing plasmapheresis and intravenous immune globulin administration has been attempted alone and in combination with varying results. We present a case report of an Rh(D) alloimmunized pregnancy, in which successful management consisted of initial therapeutic plasmapheresis (TPE) followed by intravenous immunoglobulin (IVIG) administration until delivery at 37 weeks gestation without the need for intrauterine transfusion.

Original languageEnglish (US)
Pages (from-to)183-185
Number of pages3
JournalJournal of Clinical Apheresis
Issue number6
StatePublished - 2008
Externally publishedYes


  • Hemolytic disease of the newborn
  • Intrauterine transfusion
  • Isoimmunization
  • Therapeutic plasma exchange

ASJC Scopus subject areas

  • Hematology


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