Plasma phospholipid fatty acid composition and factor VII coagulant activity

Aaron R. Folsom; Jing Ma; John H. Eckfeldt; Eyal Shahar; Kenneth K. Wu

doi:10.1016/0021-9150(94)90094-9

Plasma phospholipid fatty acid composition and factor VII coagulant activity

Aaron R. Folsom, Jing Ma, John H. Eckfeldt, Eyal Shahar, Kenneth K. Wu

Research output: Contribution to journal › Article › peer-review

16 Scopus citations

Abstract

Plasma phospholipid fatty acid composition reflects, to a moderate degree, the fatty acid composition of the diet. To determine whether plasma phospholipid fatty acid composition might influence factor VII coagulant activity (factor VII_c, we examined 2207 middle-aged adults free of diabetes and cardiovascular disease. Factor VII_c was associated positively with the percentage of fatty acids that was saturated, and it was associated negatively with the linoleic acid percentage and the phospholipid polyunsaturated/ saturated fatty acid ratio. For example, a 1.9% greater saturated fatty acid level was associated with approximately a 5% higher factor VII_c. These results suggest a role for dietary fat composition, or related dietary patterns, in determining levels of factor VII_c.

Original language	English (US)
Pages (from-to)	199-207
Number of pages	9
Journal	Atherosclerosis
Volume	111
Issue number	2
DOIs	https://doi.org/10.1016/0021-9150(94)90094-9
State	Published - Dec 1994
Externally published	Yes

Keywords

Factor VII
Fatty acids
Triglycerides

ASJC Scopus subject areas

Cardiology and Cardiovascular Medicine

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10.1016/0021-9150(94)90094-9

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@article{0eaaf8c667a44ddb9550deb812807da3,

title = "Plasma phospholipid fatty acid composition and factor VII coagulant activity",

abstract = "Plasma phospholipid fatty acid composition reflects, to a moderate degree, the fatty acid composition of the diet. To determine whether plasma phospholipid fatty acid composition might influence factor VII coagulant activity (factor VIIc, we examined 2207 middle-aged adults free of diabetes and cardiovascular disease. Factor VIIc was associated positively with the percentage of fatty acids that was saturated, and it was associated negatively with the linoleic acid percentage and the phospholipid polyunsaturated/ saturated fatty acid ratio. For example, a 1.9% greater saturated fatty acid level was associated with approximately a 5% higher factor VIIc. These results suggest a role for dietary fat composition, or related dietary patterns, in determining levels of factor VIIc.",

keywords = "Factor VII, Fatty acids, Triglycerides",

author = "Folsom, {Aaron R.} and Jing Ma and Eckfeldt, {John H.} and Eyal Shahar and Wu, {Kenneth K.}",

note = "Funding Information: This research was supported by grant ROI-HL-40848 and contracts NOI-HC-55015, NOI-HC-55016, NOI-HC-55018, NOI-HC-55019, NOI-HC-55020, NOI-HC-55021, NOl-HC-55022 from the U.S. National Heart, Lung, and Blood Institute.",

year = "1994",

month = dec,

doi = "10.1016/0021-9150(94)90094-9",

language = "English (US)",

volume = "111",

pages = "199--207",

journal = "Atherosclerosis",

issn = "0021-9150",

publisher = "Elsevier Ireland Ltd",

number = "2",

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TY - JOUR

T1 - Plasma phospholipid fatty acid composition and factor VII coagulant activity

AU - Folsom, Aaron R.

AU - Ma, Jing

AU - Eckfeldt, John H.

AU - Shahar, Eyal

AU - Wu, Kenneth K.

N1 - Funding Information: This research was supported by grant ROI-HL-40848 and contracts NOI-HC-55015, NOI-HC-55016, NOI-HC-55018, NOI-HC-55019, NOI-HC-55020, NOI-HC-55021, NOl-HC-55022 from the U.S. National Heart, Lung, and Blood Institute.

PY - 1994/12

Y1 - 1994/12

N2 - Plasma phospholipid fatty acid composition reflects, to a moderate degree, the fatty acid composition of the diet. To determine whether plasma phospholipid fatty acid composition might influence factor VII coagulant activity (factor VIIc, we examined 2207 middle-aged adults free of diabetes and cardiovascular disease. Factor VIIc was associated positively with the percentage of fatty acids that was saturated, and it was associated negatively with the linoleic acid percentage and the phospholipid polyunsaturated/ saturated fatty acid ratio. For example, a 1.9% greater saturated fatty acid level was associated with approximately a 5% higher factor VIIc. These results suggest a role for dietary fat composition, or related dietary patterns, in determining levels of factor VIIc.

AB - Plasma phospholipid fatty acid composition reflects, to a moderate degree, the fatty acid composition of the diet. To determine whether plasma phospholipid fatty acid composition might influence factor VII coagulant activity (factor VIIc, we examined 2207 middle-aged adults free of diabetes and cardiovascular disease. Factor VIIc was associated positively with the percentage of fatty acids that was saturated, and it was associated negatively with the linoleic acid percentage and the phospholipid polyunsaturated/ saturated fatty acid ratio. For example, a 1.9% greater saturated fatty acid level was associated with approximately a 5% higher factor VIIc. These results suggest a role for dietary fat composition, or related dietary patterns, in determining levels of factor VIIc.

KW - Factor VII

KW - Fatty acids

KW - Triglycerides

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U2 - 10.1016/0021-9150(94)90094-9

DO - 10.1016/0021-9150(94)90094-9

M3 - Article

C2 - 7718022

AN - SCOPUS:0028088821

SN - 0021-9150

VL - 111

SP - 199

EP - 207

JO - Atherosclerosis

JF - Atherosclerosis

IS - 2

ER -

Plasma phospholipid fatty acid composition and factor VII coagulant activity

Abstract

Keywords

ASJC Scopus subject areas

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