Plasma cathelicidin is independently associated with reduced lung function in COPD: Analysis of the subpopulations and intermediate outcome measures in COPD study cohort

the SPIROMICS collaborators

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

Rationale: The antimicrobial peptide cathelicidin, also known in humans as LL-37, is a defensin secreted by immune and airway epithelial cells. Deficiencies in this peptide may contribute to adverse pulmonary outcomes in chronic obstructive pulmonary disease (COPD). Objectives: Using clinical and biological samples from the SubPopulations and InteRmediate Outcome Measures In COPD Study (SPIROMICS), we assessed the associations of plasma cathelicidin levels with cross-sectional and longitudinal COPD outcomes. Methods: A total of 1609 SPIROMICS participants with COPD and available plasma samples were analyzed. Cathelicidin was modeled dichotomously (lowest quartile [< 50 ng/ml] versus highest 75% [≥ 50 ng/ml]) and continuously per 10 ng/ml. Fixed-effect multilevel regression analyses were used to assess associations between cathelicidin and cross-sectional as well as longitudinal lung function. The associations between cathelicidin and participant-reported retrospective and prospective COPD exacerbations were assessed via logistic regression. Measurements and Main Results: Cathelicidin < 50 ng/ml (N=383) was associated with female sex, black race, and lower body mass index (BMI). At baseline, cathelicidin < 50 ng/ml was independently associated with 3.55% lower % predicted forced expiratory volume in 1 second (FEV1)(95% confidence interval [CI] -6.22% to -0.88% predicted; p=0.01), while every 10 ng/ml lower cathelicidin was independently associated with 0.65% lower % predicted FEV1 (95% CI -1.01% to -0.28% predicted; p < 0.001). No independent associations with longitudinal lung function decline or participant-reported COPD exacerbations were observed. Conclusions: Reduced cathelicidin is associated with lower lung function at baseline. Plasma cathelicidin may potentially identify COPD patients at increased risk for more severe lung disease.

Original languageEnglish (US)
Pages (from-to)370-381
Number of pages12
JournalChronic Obstructive Pulmonary Diseases
Volume7
Issue number4
DOIs
StatePublished - 2020
Externally publishedYes

Keywords

  • COPD
  • COPD outcomes
  • Cathelicidin
  • Immunology
  • Innate immunity

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

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