Physiological functions of the giant elastic protein titin in mammalian striated muscle

Norio Fukuda, Henk L. Granzier, Shin'ichi Ishiwata, Satoshi Kurihara

Research output: Contribution to journalReview articlepeer-review

76 Scopus citations


The striated muscle sarcomere contains the third filament comprising the giant elastic protein titin, in addition to thick and thin filaments. Titin is the primary source of nonactomyosin-based passive force in both skeletal and cardiac muscles, within the physiological sarcomere length range. Titin's force repositions the thick filaments in the center of the sarcomere after contraction or stretch and thus maintains sarcomere length and structural integrity. In the heart, titin determines myocardial wall stiffness, thereby regulating ventricular filling. Recent studies have revealed the mechanisms involved in the fine tuning of titin-based passive force via alternative splicing or posttranslational modification. It has also been discovered that titin performs roles that go beyond passive force generation, such as a regulation of the Frank-Starling mechanism of the heart. In this review, we discuss how titin regulates passive and active properties of striated muscle during normal muscle function and during disease.

Original languageEnglish (US)
Pages (from-to)151-159
Number of pages9
JournalJournal of Physiological Sciences
Issue number3
StatePublished - Jun 2008


  • Ca
  • Cardiac muscle
  • Connectin
  • Skeletal muscle
  • Skinned muscle

ASJC Scopus subject areas

  • Physiology


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