Physical exosome:exosome interactions

Elie Beit-Yannai; Saray Tabak; W. Daniel Stamer

doi:10.1111/jcmm.13479

Physical exosome:exosome interactions

Elie Beit-Yannai, Saray Tabak, W. Daniel Stamer

Research output: Contribution to journal › Article › peer-review

107 Scopus citations

Abstract

Exosomes are extracellular nanovesicles that mediate a number of cellular processes, including intracellular signalling. There are many published examples of exosome–exosome dimers; however, their relevance has not been explored. Here, we propose that cells release exosomes to physically interact with incoming exosomes, forming dimers that we hypothesize attenuate incoming exosome-mediated signalling. We discuss experiments to test this hypothesis and potential relevance in health and disease.

Original language	English (US)
Pages (from-to)	2001-2006
Number of pages	6
Journal	Journal of Cellular and Molecular Medicine
Volume	22
Issue number	3
DOIs	https://doi.org/10.1111/jcmm.13479
State	Published - Mar 2018
Externally published	Yes

Keywords

exosome
hypothesis
physical interaction
signalling
zeta potential

ASJC Scopus subject areas

Molecular Medicine
Cell Biology

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10.1111/jcmm.13479

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AB - Exosomes are extracellular nanovesicles that mediate a number of cellular processes, including intracellular signalling. There are many published examples of exosome–exosome dimers; however, their relevance has not been explored. Here, we propose that cells release exosomes to physically interact with incoming exosomes, forming dimers that we hypothesize attenuate incoming exosome-mediated signalling. We discuss experiments to test this hypothesis and potential relevance in health and disease.

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KW - signalling

KW - zeta potential

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Physical exosome:exosome interactions

Abstract

Keywords

ASJC Scopus subject areas

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