Phylogenetic evidence for recombination in dengue virus

Edward C. Holmes, Michael Worobey, Andrew Rambaut

Research output: Contribution to journalArticlepeer-review

330 Scopus citations


A split decomposition analysis of dengue (DEN) virus gene sequences revealed extensive networked evolution, indicative of recombination, among DEN-1 strains but not within serotypes DEN-2, DEN-3, or DEN-4. Within DEN-1, two viruses sampled from South America in the last 10 years were identified as recombinants. To map the breakpoints and test their statistical support, we developed a novel maximum likelihood method. In both recombinants, the breakpoints were found to be in similar positions, within the fusion peptide of the envelope protein, demonstrating that a single recombination event occurred prior to the divergence of these two strains. This is the first report of recombination in natural populations of dengue virus.

Original languageEnglish (US)
Pages (from-to)405-409
Number of pages5
JournalMolecular biology and evolution
Issue number3
StatePublished - Mar 1999


  • Dengue virus
  • Maximum likelihood
  • Networks
  • Phylogeny
  • Recombination
  • Split decomposition

ASJC Scopus subject areas

  • Ecology, Evolution, Behavior and Systematics
  • Molecular Biology
  • Genetics


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