Abstract
A split decomposition analysis of dengue (DEN) virus gene sequences revealed extensive networked evolution, indicative of recombination, among DEN-1 strains but not within serotypes DEN-2, DEN-3, or DEN-4. Within DEN-1, two viruses sampled from South America in the last 10 years were identified as recombinants. To map the breakpoints and test their statistical support, we developed a novel maximum likelihood method. In both recombinants, the breakpoints were found to be in similar positions, within the fusion peptide of the envelope protein, demonstrating that a single recombination event occurred prior to the divergence of these two strains. This is the first report of recombination in natural populations of dengue virus.
Original language | English (US) |
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Pages (from-to) | 405-409 |
Number of pages | 5 |
Journal | Molecular biology and evolution |
Volume | 16 |
Issue number | 3 |
DOIs | |
State | Published - Mar 1999 |
Keywords
- Dengue virus
- Maximum likelihood
- Networks
- Phylogeny
- Recombination
- Split decomposition
ASJC Scopus subject areas
- Ecology, Evolution, Behavior and Systematics
- Molecular Biology
- Genetics