Photoredox Catalytic Installation of an Alkyl/Aryl Side Chain and Deuterium into (S)-Methyleneoxazolidinone: Synthesis of Enantioenriched α-Deuterated α-Amino Acid Derivatives

Yue Dong, Xiang Meng, Giri Gnawali, Mengyang Chang, Wei Wang

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

A photoredox catalytic asymmetric method has been established for the installation of both aliphatic and aromatic side chains and the introduction of deuterium into the chiral methyleneoxazolidinone simultaneously. Efficient coupling of readily available boronic acids with the chiral auxiliary delivers structurally diverse α-deuterated α-amino acid derivatives with a high level of diastereoselectivity and deuteration.

Original languageEnglish (US)
Pages (from-to)4745-4749
Number of pages5
JournalOrganic Letters
Volume25
Issue number25
DOIs
StatePublished - Jun 30 2023

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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