TY - JOUR
T1 - Photoelectrochemical modulation of neuronal activity with free-standing coaxial silicon nanowires
AU - Parameswaran, Ramya
AU - Carvalho-De-Souza, João L.
AU - Jiang, Yuanwen
AU - Burke, Michael J.
AU - Zimmerman, John F.
AU - Koehler, Kelliann
AU - Phillips, Andrew W.
AU - Yi, Jaeseok
AU - Adams, Erin J.
AU - Bezanilla, Francisco
AU - Tian, Bozhi
N1 - Funding Information:
We thank F. Shi at the University of Illinois Chicago for her help in collecting the EDS data. This work is supported by the Air Force Office of Scientific Research (AFOSR FA9550-14-1-0175, FA9550-15-1-0285), the National Science Foundation (NSF CAREER, DMR-1254637; NSF MRSEC, DMR 1420709), the Alfred P. Sloan Foundation Fellowship (FG-2016-6805), the Searle Scholars Foundation, the National Institute of Health (NIH GM030376, NIH F30AI138156, and NS101488), MSTP Training Grant (T32GM007281) and the Paul and Daisy Soros Foundation.
Publisher Copyright:
© 2018 The Author(s).
PY - 2018/3/1
Y1 - 2018/3/1
N2 - Optical methods for modulating cellular behaviour are promising for both fundamental and clinical applications. However, most available methods are either mechanically invasive, require genetic manipulation of target cells or cannot provide subcellular specificity. Here, we address all these issues by showing optical neuromodulation with free-standing coaxial p-type/intrinsic/n-type silicon nanowires. We reveal the presence of atomic gold on the nanowire surfaces, likely due to gold diffusion during the material growth. To evaluate how surface gold impacts the photoelectrochemical properties of single nanowires, we used modified quartz pipettes from a patch clamp and recorded sustained cathodic photocurrents from single nanowires. We show that these currents can elicit action potentials in primary rat dorsal root ganglion neurons through a primarily atomic gold-enhanced photoelectrochemical process.
AB - Optical methods for modulating cellular behaviour are promising for both fundamental and clinical applications. However, most available methods are either mechanically invasive, require genetic manipulation of target cells or cannot provide subcellular specificity. Here, we address all these issues by showing optical neuromodulation with free-standing coaxial p-type/intrinsic/n-type silicon nanowires. We reveal the presence of atomic gold on the nanowire surfaces, likely due to gold diffusion during the material growth. To evaluate how surface gold impacts the photoelectrochemical properties of single nanowires, we used modified quartz pipettes from a patch clamp and recorded sustained cathodic photocurrents from single nanowires. We show that these currents can elicit action potentials in primary rat dorsal root ganglion neurons through a primarily atomic gold-enhanced photoelectrochemical process.
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U2 - 10.1038/s41565-017-0041-7
DO - 10.1038/s41565-017-0041-7
M3 - Article
C2 - 29459654
AN - SCOPUS:85042192824
VL - 13
SP - 260
EP - 266
JO - Nature Nanotechnology
JF - Nature Nanotechnology
SN - 1748-3387
IS - 3
ER -