Phomapyrrolidones A-C, Antitubercular Alkaloids from the Endophytic Fungus Phoma sp. NRRL 46751

E. M.Kithsiri Wijeratne; Hongping He; Scott G. Franzblau; Angela M. Hoffman; A. A.Leslie Gunatilaka

doi:10.1021/np400391p

Phomapyrrolidones A-C, Antitubercular Alkaloids from the Endophytic Fungus Phoma sp. NRRL 46751

E. M.Kithsiri Wijeratne, Hongping He, Scott G. Franzblau, Angela M. Hoffman, A. A.Leslie Gunatilaka

Research output: Contribution to journal › Article › peer-review

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Abstract

Three new alkaloids, phomapyrrolidones A-C (1-3), bearing a cyclopenta[b]fluorene ring system were isolated from the mycelium extract of the endophytic fungal strain Phoma sp. NRRL 46751, inhabiting Saurauia scaberrinae. Methylation of 1 afforded its N-methyl derivative 4. The planar structures and relative configurations of 1-4 were elucidated by extensive spectroscopic analysis. Phomapyrrolidones B (2) and C (3) exhibited weak antitubercular activity at subcytotoxic concentrations.

Original language	English (US)
Pages (from-to)	1860-1865
Number of pages	6
Journal	Journal Of Natural Products
Volume	76
Issue number	10
DOIs	https://doi.org/10.1021/np400391p
State	Published - Oct 25 2013

ASJC Scopus subject areas

Analytical Chemistry
Molecular Medicine
Pharmacology
Pharmaceutical Science
Drug Discovery
Complementary and alternative medicine
Organic Chemistry

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abstract = "Three new alkaloids, phomapyrrolidones A-C (1-3), bearing a cyclopenta[b]fluorene ring system were isolated from the mycelium extract of the endophytic fungal strain Phoma sp. NRRL 46751, inhabiting Saurauia scaberrinae. Methylation of 1 afforded its N-methyl derivative 4. The planar structures and relative configurations of 1-4 were elucidated by extensive spectroscopic analysis. Phomapyrrolidones B (2) and C (3) exhibited weak antitubercular activity at subcytotoxic concentrations.",

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AU - Wijeratne, E. M.Kithsiri

AU - He, Hongping

AU - Franzblau, Scott G.

AU - Hoffman, Angela M.

AU - Gunatilaka, A. A.Leslie

PY - 2013/10/25

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AB - Three new alkaloids, phomapyrrolidones A-C (1-3), bearing a cyclopenta[b]fluorene ring system were isolated from the mycelium extract of the endophytic fungal strain Phoma sp. NRRL 46751, inhabiting Saurauia scaberrinae. Methylation of 1 afforded its N-methyl derivative 4. The planar structures and relative configurations of 1-4 were elucidated by extensive spectroscopic analysis. Phomapyrrolidones B (2) and C (3) exhibited weak antitubercular activity at subcytotoxic concentrations.

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Phomapyrrolidones A-C, Antitubercular Alkaloids from the Endophytic Fungus Phoma sp. NRRL 46751

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