Phenytoin-induced methadone withdrawal

T. G. Tong; S. M. Pond; M. J. Kreek; N. F. Jaffery; N. L. Benowitz

doi:10.7326/0003-4819-94-3-349

Phenytoin-induced methadone withdrawal

T. G. Tong, S. M. Pond, M. J. Kreek, N. F. Jaffery, N. L. Benowitz

Research output: Contribution to journal › Article › peer-review

103 Scopus citations

Abstract

Methadone-maintained volunteers experienced moderately severe opiate withdrawal symptoms within 3 or 4 days of beginning phenytoin in therapeutic doses. The area under the methadone plasma concentration-time curve decreased while the ratio of the pyrrolidine-to-metabolite excretion in urine to this area increased significantly. This suggests that phenytoin accelerates methadone metabolism. Methadone dosing adjustments should be anticipated when phenytoin is initiated or discontinued in methadone-maintained patients.

Original language	English (US)
Pages (from-to)	349-351
Number of pages	3
Journal	Unknown Journal
Volume	94
Issue number	3
DOIs	https://doi.org/10.7326/0003-4819-94-3-349
State	Published - 1981
Externally published	Yes

ASJC Scopus subject areas

Internal Medicine

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10.7326/0003-4819-94-3-349

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AU - Tong, T. G.

AU - Pond, S. M.

AU - Kreek, M. J.

AU - Jaffery, N. F.

AU - Benowitz, N. L.

PY - 1981

Y1 - 1981

N2 - Methadone-maintained volunteers experienced moderately severe opiate withdrawal symptoms within 3 or 4 days of beginning phenytoin in therapeutic doses. The area under the methadone plasma concentration-time curve decreased while the ratio of the pyrrolidine-to-metabolite excretion in urine to this area increased significantly. This suggests that phenytoin accelerates methadone metabolism. Methadone dosing adjustments should be anticipated when phenytoin is initiated or discontinued in methadone-maintained patients.

AB - Methadone-maintained volunteers experienced moderately severe opiate withdrawal symptoms within 3 or 4 days of beginning phenytoin in therapeutic doses. The area under the methadone plasma concentration-time curve decreased while the ratio of the pyrrolidine-to-metabolite excretion in urine to this area increased significantly. This suggests that phenytoin accelerates methadone metabolism. Methadone dosing adjustments should be anticipated when phenytoin is initiated or discontinued in methadone-maintained patients.

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Phenytoin-induced methadone withdrawal

Abstract

ASJC Scopus subject areas

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