Phenytoin-induced methadone withdrawal

T. G. Tong, S. M. Pond, M. J. Kreek, N. F. Jaffery, N. L. Benowitz

Research output: Contribution to journalArticlepeer-review

100 Scopus citations


Methadone-maintained volunteers experienced moderately severe opiate withdrawal symptoms within 3 or 4 days of beginning phenytoin in therapeutic doses. The area under the methadone plasma concentration-time curve decreased while the ratio of the pyrrolidine-to-metabolite excretion in urine to this area increased significantly. This suggests that phenytoin accelerates methadone metabolism. Methadone dosing adjustments should be anticipated when phenytoin is initiated or discontinued in methadone-maintained patients.

Original languageEnglish (US)
Pages (from-to)349-351
Number of pages3
JournalUnknown Journal
Issue number3
StatePublished - 1981

ASJC Scopus subject areas

  • Internal Medicine


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