TY - JOUR
T1 - Phenotypic and functional stages in the intrathymic development of αβ T cells
AU - Nikolić-Žugić, Janko
N1 - Funding Information:
The author wishes to thank F.R. Carbone for helpful discussion, M.J. Bevan for continuous support, M.J. Bevan and J. Sprent for critical review of the manuscript, and H.L. Brewer and A. Kennard for secretarial assistance. This work was funded in part by NIH grant CA25803.
PY - 1991/2
Y1 - 1991/2
N2 - The thymus is the main site o f T-cell maturation. On arrival in the thymus, CD8-CD4- double-negative (DN) T-cell precursors undergo extensive gene rearrangement, phenotypic alteration and biochemical modi fication to yield the population of thymocytes that undergoes intrathymic selection. The selected mature thymocytes then go on to seed the periphery. In this article Janko Nikolić-Žugić discusses the labyrinthine development that constitutes αβ T-cell maturation and selection.
AB - The thymus is the main site o f T-cell maturation. On arrival in the thymus, CD8-CD4- double-negative (DN) T-cell precursors undergo extensive gene rearrangement, phenotypic alteration and biochemical modi fication to yield the population of thymocytes that undergoes intrathymic selection. The selected mature thymocytes then go on to seed the periphery. In this article Janko Nikolić-Žugić discusses the labyrinthine development that constitutes αβ T-cell maturation and selection.
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U2 - 10.1016/0167-5699(91)90160-U
DO - 10.1016/0167-5699(91)90160-U
M3 - Review article
C2 - 2059306
AN - SCOPUS:0026067467
VL - 12
SP - 65
EP - 70
JO - Trends in Immunology
JF - Trends in Immunology
SN - 1471-4906
IS - 2
ER -