Phasic dopamine release evoked by abused substances requires cannabinoid receptor activation

Joseph F. Cheer; Kate M. Wassum; Leslie A. Sombers; Michael L.A.V. Heien; Jennifer L. Ariansen; Brandon J. Aragona; Paul E.M. Phillips; R. Mark Wightman

doi:10.1523/JNEUROSCI.4152-06.2007

Phasic dopamine release evoked by abused substances requires cannabinoid receptor activation

Joseph F. Cheer, Kate M. Wassum, Leslie A. Sombers, Michael L.A.V. Heien, Jennifer L. Ariansen, Brandon J. Aragona, Paul E.M. Phillips, R. Mark Wightman

Research output: Contribution to journal › Article › peer-review

297 Scopus citations

Abstract

Transient surges of dopamine in the nucleus accumbens are associated with drug seeking. Using a voltammetric sensor with high temporal and spatial resolution, we demonstrate differences in the temporal profile of dopamine concentration transients caused by acute doses of nicotine, ethanol, and cocaine in the nucleus accumbens shell of freely moving rats. Despite differential release dynamics, all drug effects are uniformly inhibited by administration of rimonabant, a cannabinoid receptor (CB1 ) antagonist, suggesting that an increase in endocannabinoid tone facilitates the effects of commonly abused drugs on subsecond dopamine release. These time-resolved chemical measurements provide unique insight into the neurobiological effectiveness of rimonabant in treating addictive disorders.

Original language	English (US)
Pages (from-to)	791-795
Number of pages	5
Journal	Journal of Neuroscience
Volume	27
Issue number	4
DOIs	https://doi.org/10.1523/JNEUROSCI.4152-06.2007
State	Published - Jan 24 2007
Externally published	Yes

Keywords

Cocaine
Cyclic voltammetry
Dopamine
Ethanol
Nicotine
Rimonabant

ASJC Scopus subject areas

General Neuroscience

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10.1523/JNEUROSCI.4152-06.2007

Cite this

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title = "Phasic dopamine release evoked by abused substances requires cannabinoid receptor activation",

abstract = "Transient surges of dopamine in the nucleus accumbens are associated with drug seeking. Using a voltammetric sensor with high temporal and spatial resolution, we demonstrate differences in the temporal profile of dopamine concentration transients caused by acute doses of nicotine, ethanol, and cocaine in the nucleus accumbens shell of freely moving rats. Despite differential release dynamics, all drug effects are uniformly inhibited by administration of rimonabant, a cannabinoid receptor (CB1 ) antagonist, suggesting that an increase in endocannabinoid tone facilitates the effects of commonly abused drugs on subsecond dopamine release. These time-resolved chemical measurements provide unique insight into the neurobiological effectiveness of rimonabant in treating addictive disorders.",

keywords = "Cocaine, Cyclic voltammetry, Dopamine, Ethanol, Nicotine, Rimonabant",

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AU - Wassum, Kate M.

AU - Sombers, Leslie A.

AU - Heien, Michael L.A.V.

AU - Ariansen, Jennifer L.

AU - Aragona, Brandon J.

AU - Phillips, Paul E.M.

AU - Wightman, R. Mark

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KW - Cyclic voltammetry

KW - Dopamine

KW - Ethanol

KW - Nicotine

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Phasic dopamine release evoked by abused substances requires cannabinoid receptor activation

Abstract

Keywords

ASJC Scopus subject areas

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